{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:32:52Z","timestamp":1782811972493,"version":"3.54.5"},"reference-count":19,"publisher":"Microbiology Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:p>This study aimed to identify strains of the <jats:italic>Candida parapsilosis<\/jats:italic> complex isolated from animals, as well as to assess their <jats:italic>in vitro<\/jats:italic> antifungal susceptibility profile and <jats:italic>in vitro<\/jats:italic> production of virulence attributes. We used 28 isolates of <jats:italic>C. parapsilosis sensu lato<\/jats:italic> recovered from clinically healthy animals. The strains were characterized phenotypically, followed by molecular identification of the species through PCR-restriction enzyme analysis. The susceptibility of the strains to amphotericin B, itraconazole, voriconazole, fluconazole and caspofungin was assessed through broth microdilution. Additionally, the ability of the strains to produce biofilm, phospholipases and proteases was analysed. Molecular analysis showed 13 <jats:italic>C. parapsilosis sensu stricto<\/jats:italic>, 10 <jats:italic>Candida orthopsilosis<\/jats:italic> and five <jats:italic>Candida metapsilosis<\/jats:italic> strains. <jats:italic>In vitro<\/jats:italic> resistance to fluconazole was observed in three strains of <jats:italic>C. parapsilosis sensu stricto<\/jats:italic> and two <jats:italic>C<\/jats:italic>. <jats:italic>metapsilosis<\/jats:italic>. All tested strains were able to form biofilms and 23\/28 isolates presented protease production, whilst none was able to produce phospholipases. Our study showed that <jats:italic>C<\/jats:italic>. <jats:italic>parapsilosis sensu stricto<\/jats:italic> and <jats:italic>C<\/jats:italic>. <jats:italic>orthopsilosis<\/jats:italic> are the most common species of the <jats:italic>C<\/jats:italic>. <jats:italic>parapsilosis<\/jats:italic> species complex and that these cryptic species present no significant phenotypical differences.<\/jats:p>","DOI":"10.1099\/jmm.0.076216-0","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T05:27:41Z","timestamp":1409894861000},"page":"1568-1572","source":"Crossref","is-referenced-by-count":21,"title":["Antifungal susceptibility and virulence attributes of animal-derived isolates of Candida parapsilosis complex"],"prefix":"10.1099","volume":"63","author":[{"given":"Raimunda S\u00e2mia Nogueira","family":"Brilhante","sequence":"first","affiliation":[{"name":"Department of Pathology and Legal Medicine, College of Medicine, Postgraduate Program in Medical 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