{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:09:23Z","timestamp":1762916963016},"reference-count":13,"publisher":"Microbiology Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,1]]},"abstract":"<jats:p>Pneumococcal disease remains an important cause of invasive and non-invasive disease in Scotland and elsewhere. The Scottish Meningococcus and Pneumococcus Reference Laboratory receives isolates of <jats:italic>Streptococcus pneumoniae<\/jats:italic> from diagnostic laboratories around Scotland. Here, the serogroups\/types and antibiotic-susceptibility patterns of invasive isolates received between 1999 and 2002 are described. There were a total of 1741 invasive isolates received, the most common serogroups\/types being 14 (19.8 %), 9 (10.2 %), 6 (8.3 %), 19 (7.9 %), 23 (7.9 %), 4 (6.5 %), 8 (6.4 %), 3 (5.7 %), 1 (3.8 %), 7 (3.8 %) and 18 (3.4 %). Importantly, serotypes 7 and 8 are not represented in the 7-, 9- and 11-valent pneumococcal conjugate polysaccharide vaccines. There were 67 (3.8 %) isolates considered penicillin non-susceptible, although no penicillin resistance (MIC \u2a7e 0.002 mg ml<jats:sup>\u22121<\/jats:sup>) was recorded. One hundred and ninety-four (11.1 %) isolates, predominantly of serotype 14, were resistant to erythromycin, and 12 (0.7 %) were resistant to ciprofloxacin. This information provides an important dataset that will prove essential prior to and during the implementation of pneumococcal conjugate vaccines in the UK.<\/jats:p>","DOI":"10.1099\/jmm.0.45718-0","type":"journal-article","created":{"date-parts":[[2005,3,15]],"date-time":"2005-03-15T21:57:57Z","timestamp":1110923877000},"page":"327-331","source":"Crossref","is-referenced-by-count":17,"title":["Serotype incidence and antibiotic susceptibility of Streptococcus pneumoniae causing invasive disease in Scotland, 1999\u20132002"],"prefix":"10.1099","volume":"54","author":[{"given":"B C","family":"Denham","sequence":"first","affiliation":[{"name":"Scottish Meningococcus and Pneumococcus Reference Laboratory, Glasgow, UK 2Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S C","family":"Clarke","sequence":"additional","affiliation":[{"name":"Scottish Meningococcus and Pneumococcus Reference Laboratory, Glasgow, UK 2Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"H1-3","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1016\/S0149-2918(03)80322-3","article-title":"Epidemiologic impact and cost-effectiveness of universal infant vaccination with a 7-valent conjugated pneumococcal vaccine in the Netherlands","volume":"25","author":"Bos","year":"2003","journal-title":"Clin Ther"},{"key":"H2-3","first-page":"2","article-title":"Surveillance of pneumococcal disease in Scotland","volume":"35","author":"Clarke","year":"2001","journal-title":"SCIEH Weekly Report"},{"key":"H3-3","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1128\/JCM.41.9.4194-4216.2003","article-title":"& 8 other authors","volume":"41","author":"Gertz","year":"2003","journal-title":"J Clin 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