{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:35:27Z","timestamp":1791160527147,"version":"4.1.0"},"reference-count":24,"publisher":"Microbiology Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,1]]},"abstract":"Plague is a natural focus-based disease, and for better understanding of this disease it is crucial to determine the molecular mechanisms of its pathogen, Yersinia pestis<\/jats:italic>, for adapting to different foci. Gene inactivation, loss and acquisition are the main mechanisms that contribute to a pathogen's fitness. Determination of the whole-genome sequences of three Y. pestis<\/jats:italic> strains, CO92, KIM and 91001, provided a good opportunity to probe into its genome in minute detail. Many genetic variations were found between the three strains. The present work focused on adaptive microevolutionary analysis of Y. pestis<\/jats:italic> from different natural plague foci in China based on pseudogene profiles. Twenty-four mutations that led to inactivation in the corresponding genes were analysed, and a PCR-based screening method was employed to investigate the distribution of these mutations among Y. pestis<\/jats:italic> isolates from different foci and also among seven strains of Yersinia pseudotuberculosis<\/jats:italic>. It was found that Y. pestis<\/jats:italic> isolates from the same focus had identical mutation profiles, and 260 isolates of Y. pestis<\/jats:italic> were divided into eight genotypes, while Y. pseudotuberculosis<\/jats:italic> harboured wild-type alleles for all the mutations. The isolates of three known biovars were grouped into distinct branches in the phylogenetic tree, which supports the proposition that biovars mediaevalis<\/jats:italic> and orientalis<\/jats:italic> directly arose from biovar antiqua<\/jats:italic> individually. The constructed phylogenetic tree suggests that the isolates from focus B should be the oldest lineage of Y. pestis<\/jats:italic> in China except for isolates from foci L and M, which might be a special lineage of Y. pestis<\/jats:italic> and originated differently to the others.<\/jats:p>","DOI":"10.1099\/jmm.0.45752-0","type":"journal-article","created":{"date-parts":[[2005,2,16]],"date-time":"2005-02-16T00:47:29Z","timestamp":1108514849000},"page":"259-268","source":"Crossref","is-referenced-by-count":34,"title":["Pseudogene accumulation might promote the adaptive microevolution of Yersinia pestis"],"prefix":"10.1099","volume":"54","author":[{"given":"Zongzhong","family":"Tong","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decui","family":"Pei","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Pang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baizhong","family":"Cui","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaobiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhen","family":"Qi","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Zhai","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongmin","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, No. 20 Dongdajie, Fengtai, Beijing 100071, China 2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 3Qinghai Institute for Endemic Diseases Prevention and Control, Xining 811602, 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Yersinia pestis","volume":"38","author":"Adair","year":"2000","journal-title":"J Clin Microbiol"},{"key":"H3-7","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1128\/JB.184.16.4601-4611.2002","article-title":"III & 18 other authors","volume":"184","author":"Deng","year":"2002","journal-title":"J Bacteriol"},{"key":"H4-7","first-page":"340","article-title":"The pathogenicity of Yersinia pestis of Xilin Gol grassland type","volume":"9","author":"Fan","year":"1994","journal-title":"Chin J Control Endemic Dis"},{"key":"H5-7","first-page":"56","article-title":"Microtus brandti plague in the Xilin Gol Grassland was inoffensive to humans","volume":"10","author":"Fan","year":"1995","journal-title":"Chin J Control Endemic Dis"},{"key":"H6-7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1056\/NEJM199709043371004","article-title":"Multidrug resistance in Yersinia pestis mediated by a transferable plasmid","volume":"337","author":"Galimand","year":"1997","journal-title":"N 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