{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:52:11Z","timestamp":1775152331074,"version":"3.50.1"},"reference-count":20,"publisher":"Microbiology Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"<jats:p>The antimicrobial resistance of 122 <jats:italic>Shigella sonnei<\/jats:italic> isolates obtained in Korea during the period 1991\u20132000 was characterized. These isolates were highly resistant to traditional antibiotics such as trimethoprim (100\u200a%), streptomycin (100\u200a%), sulfamethoxazole (94\u200a%), tetracycline (93\u200a%) and nalidixic acid (90\u200a%). All <jats:italic>S. sonnei<\/jats:italic> isolates carried Tn<jats:italic>7<\/jats:italic> in their chromosomes. The 8.4\u2005kb non-transferable resistance (R) plasmid carrying <jats:italic>tetA<\/jats:italic>, <jats:italic>strA-strB<\/jats:italic> and <jats:italic>sul1<\/jats:italic> was found in 93\u200a% of the <jats:italic>S. sonnei<\/jats:italic> isolates. Resistance to nalidixic acid first appeared in a <jats:italic>S. sonnei<\/jats:italic> isolate in 1997, and then in all <jats:italic>S. sonnei<\/jats:italic> isolates from 1998 and 1999. Resistance to commonly prescribed antibiotics such as ampicillin was increased in <jats:italic>S. sonnei<\/jats:italic> isolates during the outbreak period 1998\u20132000. Resistance to ampicillin was mediated by the conjugative R plasmids carrying <jats:italic>bla<\/jats:italic>\n                  <jats:sub>TEM-1<\/jats:sub>. In conclusion, <jats:italic>S. sonnei<\/jats:italic> acquired antimicrobial resistance to commonly prescribed antibiotics through the horizontal transfer of conjugative R plasmids, while the genetic stability of transposon and non-transferable R plasmids was responsible for resistance to traditional antibiotics.<\/jats:p>","DOI":"10.1099\/jmm.0.46441-0","type":"journal-article","created":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T16:53:51Z","timestamp":1150217631000},"page":"871-877","source":"Crossref","is-referenced-by-count":31,"title":["Molecular characterization of antimicrobial resistance in Shigella sonnei isolates in Korea"],"prefix":"10.1099","volume":"55","author":[{"given":"Sung Yong","family":"Seol","sequence":"first","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sook","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Chan","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Taek","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/nar\/7.6.1513","article-title":"A rapid alkaline extraction procedure for screening recombinant plasmid DNA","volume":"7","author":"Birnboim","year":"1979","journal-title":"Nucleic Acids Res"},{"key":"R2","first-page":"27","article-title":"Drug resistance of Shigella and Salmonella and the inhibition and elimination of drug resistance","volume":"14","author":"Chun","year":"1979","journal-title":"J Korean Soc Microbiol"},{"key":"R3","volume-title":"Edwards and Ewing's Identification of Enterobacteriaceae","author":"Ewing","year":"1986"},{"key":"R4","first-page":"1","article-title":"Studies on the Shigella isolated in Southern Korea with reference to non- Shigella strains possessing Shigella antigens","volume":"20","author":"Im","year":"1961","journal-title":"Showa Med J"},{"key":"R5","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1128\/AAC.47.12.3719-3723.2003","article-title":"& 7 other authors","volume":"47","author":"Jeong","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"R6","first-page":"106","article-title":"Epidemiological typing and characterization of dfr genes of Shigella sonnei isolates in Korea during the last two decades","volume":"12","author":"Kim","year":"2002","journal-title":"J Microbiol Biotechnol"},{"key":"R7","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1128\/JCM.42.11.5264-5269.2004","article-title":"Occurrence of extended-spectrum \u03b2 -lactamases in members of the genus Shigella in the Republic of Korea","volume":"42","author":"Kim","year":"2004","journal-title":"J Clin Microbiol"},{"key":"R8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/jac\/47.5.599","article-title":"The prevalence of trimethoprim-resistance-conferring dihydrofolate reductase genes in urinary isolates of Escherichia coli in Korea","volume":"47","author":"Lee","year":"2001a","journal-title":"J Antimicrob Chemother"},{"key":"R9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1034\/j.1600-0463.2001.090307.x","article-title":"Antimicrobial resistance of Shigella sonnei in Korea during the last two decades","volume":"109","author":"Lee","year":"2001b","journal-title":"APMIS"},{"key":"R10","volume-title":"National Committee for Clinical Laboratory Standards","year":"1997"},{"key":"R11","volume-title":"National Institute of Health in Korea","year":"2005"},{"key":"R12","first-page":"591","article-title":"Antimicrobial resistance and R plasmids in Shigella","volume":"20","author":"Oh","year":"1977","journal-title":"Korean J Internal Med"},{"key":"R13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1034\/j.1600-0463.2002.100307.x","article-title":"Epidemiological typing and prevalence of integrons in multiresistant Acinetobacter strains","volume":"110","author":"Oh","year":"2002","journal-title":"APMIS"},{"key":"R14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1128\/JCM.41.1.421-423.2003","article-title":"Changes in patterns of antimicrobial susceptibility and integron carriage among Shigella sonnei isolates from southwestern Korea during epidemic periods","volume":"41","author":"Oh","year":"2003","journal-title":"J Clin Microbiol"},{"key":"R15","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1128\/JCM.39.10.3747-3749.2001","article-title":"Identification of CTX-M-14 extended-spectrum \u03b2 -lactamase in clinical isolates of Shigella sonnei , Escherichia coli , and Klebsiella pneumoniae in Korea","volume":"39","author":"Pai","year":"2001","journal-title":"J Clin Microbiol"},{"key":"R16","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/JCM.33.9.2233-2239.1995","article-title":"Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing","volume":"33","author":"Tenover","year":"1995","journal-title":"J Clin Microbiol"},{"key":"R17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF01967070","article-title":"Monitoring of antibiotic resistance in Shigella isolated in the Netherlands 1984\u20131989","volume":"11","author":"Voogd","year":"1992","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1574-6968.2000.tb08906.x","article-title":"Characterization of the two gene cassettes, aadA5 and dfrA17","volume":"182","author":"White","year":"2000","journal-title":"FEMS Microbiol Lett"},{"key":"R19","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1128\/AAC.45.9.2658-2661.2001","article-title":"Integrons and gene cassettes in the Enterobacteriaceae","volume":"45","author":"White","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"R20","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1128\/JCM.41.12.5429-5433.2003","article-title":"& 9 other authors","volume":"41","author":"Yu","year":"2003","journal-title":"J Clin Microbiol"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.46441-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T03:35:20Z","timestamp":1600832120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.46441-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,1]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.46441-0","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,1]]}}}