{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:46:53Z","timestamp":1792100813143,"version":"4.4.0"},"reference-count":7,"publisher":"Microbiology Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:p>Traditional sampling methods for the diagnosis of oral candidosis in head and neck cancer patients, i.e. saliva collection or tongue scrapings, are often impossible to perform. The aim was to determine the optimal sampling method. Eighteen oral cancer patients and five control subjects were sampled semi-quantitatively from the labial sulcus, dorsum of the tongue, dental plaque and saliva for cultivation of yeasts. The patients were examined prior to all cancer treatment (<jats:italic>n<\/jats:italic>=5), or 2\u20134\u2005weeks (<jats:italic>n<\/jats:italic>=5) or 8\u201312\u2005weeks (<jats:italic>n<\/jats:italic>=8) post-operatively. The incidence of <jats:italic>Candida<\/jats:italic> was found to increase from 40\u200a% at the control and pre-operative level up to 73\u200a% 8\u201312\u2005weeks post-operatively. <jats:italic>Candida albicans<\/jats:italic> was found to be the only species until 4\u2005weeks post-operatively. Thereafter, the incidence of species other than <jats:italic>C. albicans<\/jats:italic> was 38\u200a%. The most sensitive sampling site was found to be the vestibular sulcus, from which all culture-positive cases could be confirmed. Tongue surface scraping was found to be more sensitive than saliva collection in detecting <jats:italic>Candida<\/jats:italic>. All sampling methods and sites were equally sensitive in detecting the different <jats:italic>Candida<\/jats:italic> species. Dental plaque was found to have the highest density of <jats:italic>Candida<\/jats:italic> colonization, and was thus found to be the most significant source of <jats:italic>Candida<\/jats:italic> infection, which emphasizes the role of dental care in these patients.<\/jats:p>","DOI":"10.1099\/jmm.0.46615-0","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T17:08:20Z","timestamp":1159376900000},"page":"1447-1451","source":"Crossref","is-referenced-by-count":23,"title":["Optimal sampling site for mucosal candidosis in oral cancer patients is the labial sulcus"],"prefix":"10.1099","volume":"55","author":[{"given":"Riina","family":"Rautemaa","sequence":"first","affiliation":[{"name":"Microbiology Unit of Helsinki University Central Hospital (HUCH) Laboratory Diagnostics, Helsinki, Finland"},{"name":"Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital (HUCH), Helsinki, Finland"},{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rusanen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry, University of Helsinki, Helsinki, Finland"},{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Richardson","sequence":"additional","affiliation":[{"name":"Microbiology Unit of Helsinki University Central Hospital (HUCH) Laboratory Diagnostics, Helsinki, Finland"},{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka H.","family":"Meurman","sequence":"additional","affiliation":[{"name":"Institute of Dentistry, University of Helsinki, Helsinki, Finland"},{"name":"Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital (HUCH), Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1191\/0269216303pm793oa","article-title":"High prevalence of non-albicans yeasts and detection of anti-fungal resistance in the oral flora of patients with advanced cancer","volume":"17","author":"Bagg","year":"2003","journal-title":"Palliat Med"},{"key":"R2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1399-302x.2004.00165.x","article-title":"Oral Candida isolates in patients undergoing radiotherapy for head and neck cancer: prevalence, azole susceptibility profiles and response to antifungal treatment","volume":"19","author":"Belazi","year":"2004","journal-title":"Oral Microbiol Immunol"},{"key":"R3","volume-title":"Candida and Candidiasis","author":"Calderone","year":"2002"},{"key":"R4","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1128\/JCM.37.12.3896-3900.1999","article-title":"& 7 other authors","volume":"37","author":"Redding","year":"1999","journal-title":"J Clin Microbiol"},{"key":"R5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tripleo.2003.09.008","article-title":"Candida glabrata is an emerging cause of oropharyngeal candidiasis in patients receiving radiation for head and neck cancer","volume":"97","author":"Redding","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R6","doi-asserted-by":"crossref","DOI":"10.1002\/9780470755259","volume-title":"Fungal Infection; Diagnosis and Management","author":"Richardson","year":"2003"},{"key":"R7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.radonc.2004.11.004","article-title":"Intensity modulated radiotherapy for head and neck cancer: evidence for preserved salivary gland function","volume":"74","author":"Saarilahti","year":"2005","journal-title":"Radiother Oncol"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.46615-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T04:15:43Z","timestamp":1600834543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.46615-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,1]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.46615-0","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,1]]}}}