{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:37:22Z","timestamp":1773283042988,"version":"3.50.1"},"reference-count":14,"publisher":"Microbiology Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,1]]},"abstract":"<jats:p>This report describes a case of ciprofloxacin treatment failure in a patient with enteric fever caused by <jats:italic>Salmonella enterica<\/jats:italic> serotype Paratyphi A. The organism was isolated from a blood culture from a patient who was treated with oral ciprofloxacin (500\u2005mg every 12\u2005h) for 13\u2005days. The organism showed reduced susceptibility to ciprofloxacin (MIC 0.75\u2005\u03bcg\u2005ml<jats:sup>\u22121<\/jats:sup>) and was resistant to nalidixic acid. The patient was then placed on intravenous ceftriaxone (1\u2005g every 12\u2005h) and responded within 3 days. The patient was discharged after 9\u2005days on ceftriaxone with no relapse on follow-up. This case adds to the increasing incidence of treatment failures with ciprofloxacin in typhoid fever caused by typhoid salmonellae with reduced susceptibility to ciprofloxacin. It also highlights the inadequacy of current laboratory methods for fluoroquinolone susceptibility testing in adequately predicting <jats:italic>in vivo<\/jats:italic> activity of ciprofloxacin against typhoid salmonellae and supports calls for new guidelines for fluoroquinolone susceptibility testing of these organisms.<\/jats:p>","DOI":"10.1099\/jmm.0.46773-0","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T21:03:47Z","timestamp":1169586227000},"page":"277-279","source":"Crossref","is-referenced-by-count":34,"title":["Ciprofloxacin treatment failure in a case of typhoid fever caused by Salmonella enterica serotype Paratyphi A with reduced susceptibility to ciprofloxacin"],"prefix":"10.1099","volume":"56","author":[{"given":"Tzonyo","family":"Dimitrov","sequence":"first","affiliation":[{"name":"Department of Medical Laboratories, Microbiology Section, Infectious Diseases Hospital, PO Box 4710, Safat 13048, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edet E.","family":"Udo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Albaksami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Infectious Diseases Hospital, PO Box 4710, Safat 13048, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul A.","family":"Kilani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases Hospital, PO Box 4710, Safat 13048, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El-Din M. 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