{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:16:18Z","timestamp":1777349778403,"version":"3.51.4"},"reference-count":18,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:p>\n                  <jats:italic>Salmonella enterica<\/jats:italic> subspecies <jats:italic>enterica<\/jats:italic> serovar Paratyphi B [O1,4,(5),12\u200a:\u200aHb\u200a:\u200a1,2] can cause either an enteric fever (paratyphoid fever) or self-limiting gastroenteritis in humans. The <jats:italic>d<\/jats:italic>-tartrate non-fermenting variant <jats:italic>S. enterica<\/jats:italic> subsp. <jats:italic>enterica<\/jats:italic> serovar Paratyphi B dT<jats:sup>\u2212<\/jats:sup> (<jats:italic>S<\/jats:italic>. Paratyphi B) is the causative agent of paratyphoid fever, and the <jats:italic>d<\/jats:italic>-tartrate fermenting variant <jats:italic>S. enterica<\/jats:italic> subsp. <jats:italic>enterica<\/jats:italic> serovar Paratyphi B dT<jats:sup>+<\/jats:sup> (<jats:italic>S<\/jats:italic>. Paratyphi B dT<jats:sup>+<\/jats:sup>; formerly called <jats:italic>Salmonella<\/jats:italic> Java) causes gastroenteritis. <jats:italic>S<\/jats:italic>. Java is currently recognized as an emerging problem worldwide. Twelve dT<jats:sup>+<\/jats:sup> \n                  <jats:italic>S<\/jats:italic>. Java isolates were collected in Indonesia between 2000 and 2002. One-third of them contained <jats:italic>Salmonella<\/jats:italic> genomic island 1 (SGI1), which gives the multidrug-resistant phenotype to the bacteria. In this study, a PCR-based method to detect a single nucleotide difference responsible for the inability to ferment <jats:italic>d<\/jats:italic>-tartrate, reported elsewhere, was validated. The <jats:italic>d<\/jats:italic>-tartrate fermenting phenotype of <jats:italic>S<\/jats:italic>. Java was converted to the non-fermenting phenotype by the disruption of the ORF STM 3356, and the <jats:italic>d<\/jats:italic>-tartrate non-fermenting phenotype of the ORF STM 3356-disrupted strain and the dT<jats:sup>\u2212<\/jats:sup> reference strain was changed to the dT<jats:sup>+<\/jats:sup> phenotype by complementing ORF STM 3356 <jats:italic>in trans<\/jats:italic>. The results show that the dT<jats:sup>+<\/jats:sup> phenotype requires a functional product encoded by STM 3356, and support the use of the PCR-based discrimination method for <jats:italic>S<\/jats:italic>. Paratyphi B and <jats:italic>S<\/jats:italic>. Java as the standard differentiation method.<\/jats:p>","DOI":"10.1099\/jmm.0.46792-0","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T03:24:42Z","timestamp":1163647482000},"page":"1661-1665","source":"Crossref","is-referenced-by-count":12,"title":["Isolation of Salmonella enterica subspecies enterica serovar Paratyphi B dT+, or Salmonella Java, from Indonesia and alteration of the d-tartrate fermentation phenotype by disrupting the ORF STM 3356"],"prefix":"10.1099","volume":"55","author":[{"given":"Kyung Ho","family":"Han","sequence":"first","affiliation":[{"name":"International Vaccine Institute, San 4-8 Bongcheon 7 dong, Kwanak gu, Seoul, 151-818, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon Young","family":"Choi","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, San 4-8 Bongcheon 7 dong, Kwanak gu, Seoul, 151-818, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, San 4-8 Bongcheon 7 dong, Kwanak gu, Seoul, 151-818, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejon","family":"Lee","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, San 4-8 Bongcheon 7 dong, Kwanak gu, Seoul, 151-818, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Hee","family":"Shin","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, San 4-8 Bongcheon 7 dong, Kwanak gu, Seoul, 151-818, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdarina D.","family":"Agtini","sequence":"additional","affiliation":[{"name":"National Institute of Health Research and Development, Ministry of Health, Jakarta, 10560, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenz","family":"von Seidlein","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, San 4-8 Bongcheon 7 dong, Kwanak gu, Seoul, 151-818, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Leon","family":"Ochiai","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, San 4-8 Bongcheon 7 dong, Kwanak gu, Seoul, 151-818, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Clemens","sequence":"additional","affiliation":[{"name":"International Vaccine Institute, San 4-8 Bongcheon 7 dong, Kwanak gu, Seoul, 151-818, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Wain","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Sook","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bok Kwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Enteric Infections, Department of Microbiology, National Institute of Health Korea, 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