{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:47:18Z","timestamp":1773294438707,"version":"3.50.1"},"reference-count":20,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:p>The purpose of this study was to compare the frequency of recovery of aerobic and anaerobic organisms with interfering capability against group A <jats:italic>\u03b2<\/jats:italic>-haemolytic streptococci (GABHS) and <jats:italic>\u03b2<\/jats:italic>-lactamase-producing bacteria (BLPB) from the tonsils of GABHS carriers and non-carriers. The presence of aerobic and anaerobic bacteria capable of such interference <jats:italic>in vitro<\/jats:italic> was evaluated in cultures obtained from the tonsils of 20 healthy children who were non-GABHS carriers and 20 who were GABHS carriers, and also from 20 children who were asymptomatic after completing a course of penicillin for acute GABHS pharyngo-tonsillitis (PT) and were non-GABHS carriers and 20 who were GABHS carriers. In healthy children, 32 interfering isolates were recovered from 16 non-GABHS carriers (1.6 per child) and 13 were isolated from 7 GABHS carriers (0.65 per child) (<jats:italic>P<\/jats:italic>&lt;0.001). In children who had suffered acute GABHS PT, 26 interfering organisms were recovered from 15 non-GABHS carriers (1.3 per child) and 8 were isolated from 5 GABHS carriers (0.4 per child) (<jats:italic>P<\/jats:italic>&lt;0.005). In healthy children, 13 BLPB were recovered from 5 non-GABHS carriers and 13 were isolated from 6 GABHS carriers. In children who had suffered acute GABHS PT, 14 BLPB were recovered from 5 (25\u200a%) non-GABHS carriers and 32 were isolated from 17 (85\u200a%) GABHS carriers (<jats:italic>P<\/jats:italic>&lt;0.05). It was demonstrated in this study that there was a higher rate of recovery of aerobic and anaerobic organisms capable of interfering with GABHS in non-GABHS carriers than in GABHS carriers. This was observed in all GABHS non-carriers and included healthy children as well as those recently treated for symptomatic GABHS PT with penicillin that failed to eradicate GABHS. A higher rate of recovery of BLPB was observed only in GABHS carriers who were treated with penicillin for GABHS PT.<\/jats:p>","DOI":"10.1099\/jmm.0.46796-0","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T03:24:42Z","timestamp":1163647482000},"page":"1741-1744","source":"Crossref","is-referenced-by-count":8,"title":["Recovery of interfering and \u03b2-lactamase-producing bacteria from group A \u03b2-haemolytic streptococci carriers and non-carriers"],"prefix":"10.1099","volume":"55","author":[{"given":"Itzhak","family":"Brook","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan E.","family":"Gober","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Georgetown University School of Medicine, Washington DC, 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