{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:38:47Z","timestamp":1793137127551,"version":"4.5.0"},"reference-count":10,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,1]]},"abstract":"<jats:p>Interleukin-1 receptor-associated kinase (IRAK)-4 deficiency is a rare primary immunodeficiency disorder characterized by severe, invasive infections with <jats:italic>Streptococcus pneumoniae<\/jats:italic>. Using the PFGE technique a genetic linkage was found between two <jats:italic>S. pneumoniae<\/jats:italic> serotype 14 isolates causing arthritis and meningitis at 3 and 5\u00bd years of age, respectively, in a boy with IRAK-4 deficiency. This finding suggested that patients with IRAK-4 deficiency may harbour persistent strains of pneumococci. Alternatively, reinfection with strains from close contacts of the patient might cause recurrent invasive disease. It is proposed that eradication of pneumococci from the nasopharynx, and immunization of household contacts may prevent recurrent infection in IRAK-4-deficient patients.<\/jats:p>","DOI":"10.1099\/jmm.0.47046-0","type":"journal-article","created":{"date-parts":[[2007,5,17]],"date-time":"2007-05-17T22:41:59Z","timestamp":1179441719000},"page":"863-865","source":"Crossref","is-referenced-by-count":19,"title":["Recurrent infection with genetically identical pneumococcal isolates in a patient with interleukin-1 receptor-associated kinase-4 deficiency"],"prefix":"10.1099","volume":"56","author":[{"given":"Judit","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Dobay","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Faculty of Medicine, Semmelweis 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