{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:25:42Z","timestamp":1778714742630,"version":"3.51.4"},"reference-count":37,"publisher":"Microbiology Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:p><jats:italic>Candida glabrata<\/jats:italic>is the second or third most frequent cause of candidaemia. The gastrointestinal tract is considered to be a major portal of entry for systemic candidiasis, but relatively few studies have investigated the pathogenesis of<jats:italic>C. glabrata<\/jats:italic>. Experiments were designed to clarify the ability of<jats:italic>C. glabrata<\/jats:italic>to disseminate from the mouse intestinal tract. Following oral inoculation,<jats:italic>C. glabrata<\/jats:italic>readily colonized the caeca [approx. 10<jats:sup>7<\/jats:sup>cells (g caecum)<jats:sup>\u22121<\/jats:sup>] of antibiotic-treated mice, but extraintestinal dissemination was not detected. Superimposing several mouse models of trauma and\/or immunosuppression known to induce dissemination of<jats:italic>Candida albicans<\/jats:italic>and other intestinal microbes did not cause<jats:italic>C. glabrata<\/jats:italic>to disseminate often, although one exception was mice given high doses of dexamethasone for 4 days. These data support the hypothesis that the antibiotic-treated mouse intestine may be an epidemiological reservoir for<jats:italic>C. glabrata<\/jats:italic>and that this yeast tends to disseminate under specific clinical conditions.<\/jats:p>","DOI":"10.1099\/jmm.0.47049-0","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T16:34:20Z","timestamp":1177000460000},"page":"688-693","source":"Crossref","is-referenced-by-count":11,"title":["Candida glabrata colonizes but does not often disseminate from the mouse caecum"],"prefix":"10.1099","volume":"56","author":[{"given":"Carol L.","family":"Wells","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Minnesota, Minneapolis, MN 55455-0374, USA"},{"name":"Department of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN 55455-0374, 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