{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:30:43Z","timestamp":1785828643582,"version":"3.56.0"},"reference-count":67,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:p>A case\u2013control study was conducted to identify the aetiology of diarrhoeal diseases in pre-school children in a suburban area of Hanoi where the use of untreated wastewater in agriculture and aquaculture is a common practice. Stool specimens and clinical information were collected from 111 pairs of children with diarrhoea and healthy controls. A total of 73 cases (66\u200a%) and 41 controls (36\u200a%) had an enteric pathogen. The pathogens most often associated with diarrhoea were rotavirus (17\u200a% of cases) and <jats:italic>Entamoeba histolytica<\/jats:italic> (15\u200a%), followed by <jats:italic>Shigella<\/jats:italic> (5\u200a%). Diarrhoeagenic <jats:italic>Escherichia coli<\/jats:italic> (DEC) was found in 23\u200a% of both patients and controls. Characterization of DEC by serotyping, antimicrobial susceptibility test and PFGE showed that DEC represented by different pathotypes belonged to various serotypes. Except for three enterotoxigenic <jats:italic>E. coli<\/jats:italic> strains, typing by PFGE revealed no correlation between pathotype and serotype of DEC strains. This suggests a high prevalence of a variety of DEC subtypes in this area. For this particular region, vaccine development strategies targeting rotavirus and <jats:italic>Shigella<\/jats:italic> are likely to be of public health benefit, whereas the role of DEC and preventive measures need to be further elaborated.<\/jats:p>","DOI":"10.1099\/jmm.0.47093-0","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T17:52:59Z","timestamp":1184953979000},"page":"1086-1096","source":"Crossref","is-referenced-by-count":39,"title":["Diarrhoeagenic Escherichia coli and other causes of childhood diarrhoea: a case\u2013control study in children living in a wastewater-use area in Hanoi, Vietnam"],"prefix":"10.1099","volume":"56","author":[{"given":"Bui Thi Thu","family":"Hien","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology, Faculty of Life Science, Copenhagen University, Frederiksberg, Denmark"},{"name":"Department of Microbiology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Thuy","family":"Trang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Scheutz","sequence":"additional","affiliation":[{"name":"International Escherichia and Klebsiella Centre (WHO), Department of Bacteriology, Mycology, and Parasitology, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phung Dac","family":"Cam","sequence":"additional","affiliation":[{"name":"Department of Microbiology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re","family":"M\u00f8lbak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Dalsgaard","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Faculty of Life Science, Copenhagen University, Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1128\/JCM.37.11.3458-3464.1999","article-title":"Case\u2013control study of enteropathogens associated with childhood diarrhea in Dhaka","volume":"37","author":"Albert","year":"1999","journal-title":"Bangladesh. 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