{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:38:42Z","timestamp":1774352322996,"version":"3.50.1"},"reference-count":29,"publisher":"Microbiology Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:p>Germfree transgenic epsilon 26 mice (Tg\u03f526), deficient in natural killer cells and T cells, were colonized (alimentary tract) with<jats:italic>Candida albicans<\/jats:italic>wild-type or each of two hyphal transcription factor signalling mutant strains (<jats:italic>efg1\/efg1<\/jats:italic>,<jats:italic>efg1\/efg1 cph1\/cph1<\/jats:italic>). Each<jats:italic>Candida<\/jats:italic>strain colonized the alimentary tract, infected keratinized gastric tissues to a similar extent, and induced a granulocyte-dominated inflammatory response in infected tissues. Both wild-type and mutant strains formed hyphae<jats:italic>in vivo<\/jats:italic>and were able to elicit an increase in cytokine [tumour necrosis factor alpha, interleukin (IL)-10 and IL-12] and chemokine (KC and macrophage inflammatory protein-2] mRNAs in infected tissues; however, administration of the wild-type strain was lethal for the Tg\u03f526 mice, whereas the mice colonized with the mutant strains survived. Death of the Tg\u03f526-colonized mice appeared to be due to occlusive oesophageal candidiasis, and not to disseminated candidiasis of endogenous origin. In contrast, the mutant strains exhibited a significantly reduced capacity to infect (frequency and severity) oro-oesophageal (tongue and oesophagus) tissues. Therefore, the two hyphal signalling-defective mutants were less able to infect oro-oesophageal tissues and were non-lethal, but retained their ability to colonize the alimentary tract with yeast and hyphae, infect keratinized gastric tissues, and evoke an inflammatory response in orogastric tissues.<\/jats:p>","DOI":"10.1099\/jmm.0.47110-0","type":"journal-article","created":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T17:28:00Z","timestamp":1188408480000},"page":"1138-1144","source":"Crossref","is-referenced-by-count":11,"title":["Susceptibility of gnotobiotic transgenic mice (Tg\u03f526) with combined deficiencies in natural killer cells and T cells to wild-type and hyphal signalling-defective mutants of Candida albicans"],"prefix":"10.1099","volume":"56","author":[{"given":"Caroline","family":"Westwater","sequence":"first","affiliation":[{"name":"Department of Stomatology, Medical University of South Carolina, Charleston, SC, 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