{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:09:05Z","timestamp":1790474945335,"version":"4.1.0"},"reference-count":21,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:p>A worldwide selection of more than 200 isolates of the anthropophilic dermatophyte<jats:italic>Trichophyton rubrum<\/jats:italic>were analysed using seven microsatellite markers. Fifty-five multilocus genotypes were recognized, allowing a subdivision of the species into two populations. Both populations reproduced strictly clonally, showed a different predilection on the human host (scalp vs foot) and displayed geographic differentiation. Genotypes of one population originated predominantly from Africa, whilst the second population showed a worldwide distribution excluding the African continent. Genotypic diversity was highest in the African population, despite the lower number of strains analysed, suggesting that<jats:italic>T. rubrum<\/jats:italic>is likely to have evolved in Africa. No diagnostic correlation was observed between multilocus genotypes and any of the phenotypical characteristics of the strains. The involvement of multiple strains in a single patient detected by workers using other typing methods was not supported by these microsatellite markers. Four of the developed microsatellite markers may be applied for diagnostic purposes.<\/jats:p>","DOI":"10.1099\/jmm.0.47138-0","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T17:52:59Z","timestamp":1184953979000},"page":"1058-1065","source":"Crossref","is-referenced-by-count":63,"title":["Microsatellite markers reveal geographic population differentiation in Trichophyton rubrum"],"prefix":"10.1099","volume":"56","author":[{"given":"Yvonne","family":"Gr\u00e4ser","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Hygiene (Charit\u00e9), Humboldt University, Dorotheenstr. 96, D-10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Hygiene (Charit\u00e9), Humboldt University, Dorotheenstr. 96, D-10117 Berlin, 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