{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:14:33Z","timestamp":1760548473610},"reference-count":20,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:p>Internalin A is a surface protein of the facultative intracellular pathogen <jats:italic>Listeria monocytogenes<\/jats:italic> that interacts with the human host cell protein E-cadherin to facilitate invasion of epithelial cells. A single amino acid substitution at position 16 in mouse E-cadherin prevents this interaction. Synthetic polypeptides of 30 aa encompassing position 16 of human and mouse E-cadherin were tested for their ability to inhibit <jats:italic>in vitro<\/jats:italic> invasion of Caco-2, HepG2 and TIB73 cell lines by <jats:italic>L. monocytogenes<\/jats:italic>. Only the human-derived peptide was capable of inhibiting invasion in the human-origin Caco-2 and HepG2 cell lines. These findings demonstrate that small polypeptides can inhibit invasion of biologically relevant cell types by <jats:italic>L. monocytogenes in vitro<\/jats:italic> and may be potentially useful as therapeutic agents <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1099\/jmm.0.47194-0","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T17:52:59Z","timestamp":1184953979000},"page":"1011-1016","source":"Crossref","is-referenced-by-count":9,"title":["A synthetic polypeptide based on human E-cadherin inhibits invasion of human intestinal and liver cell lines by Listeria monocytogenes"],"prefix":"10.1099","volume":"56","author":[{"given":"Saura C.","family":"Sahu","sequence":"first","affiliation":[{"name":"Immunobiology Branch, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD 20708, 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