{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T10:03:41Z","timestamp":1710842621106},"reference-count":17,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"\n Candida<\/jats:italic> species are the fourth most common cause of bloodstream infection (BSI) in the hospitalized patient. Candida glabrata<\/jats:italic> is the most common non-Candida albicans Candida<\/jats:italic> species in England and Wales with an attributed mortality of 48\u200a%. C. glabrata<\/jats:italic> is known to demonstrate reduced susceptibility to fluconazole, resulting in treatment failures when employing this agent for empirical treatment of Candida<\/jats:italic> BSI. The first part of this study demonstrated a technique utilizing a blood culture system commonly used by many laboratories (BACTEC 9240 automated detection system) that reduced the time to identification of this potentially resistant organism by up to 72\u2005h. A presumptive identification was achieved by observing a difference in the duration of incubation required before growth was detected automatically between Lytic Anaerobic and Plus Aerobic culture bottles. Secondly, experiments exploring the growth characteristics of C. glabrata<\/jats:italic> in BACTEC blood culture bottles containing various media were carried out to explore possible reasons underpinning this clinical observation. The detection of yeast in the anaerobic bottle of a blood culture pair consisting of Lytic Anaerobic and Plus Aerobic in a BACTEC 9240 system was found to be highly predictive of the isolation of C. glabrata<\/jats:italic> (positive predictive value 93.3\u200a%, negative predictive value 98.3\u200a%). The reason for this appeared to be a component of the Lytic Anaerobic blood culture medium enhancing the growth of C. glabrata<\/jats:italic> in that medium.<\/jats:p>","DOI":"10.1099\/jmm.0.47406-0","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T18:42:53Z","timestamp":1195756973000},"page":"1639-1643","source":"Crossref","is-referenced-by-count":22,"title":["Rapid identification of Candida glabrata in Candida bloodstream infections"],"prefix":"10.1099","volume":"56","author":[{"given":"Nicholas","family":"Foster","sequence":"first","affiliation":[{"name":"Department of Mycology, The Old Medical School, Thorseby Place, Leeds LS2 9JT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Symes","sequence":"additional","affiliation":[{"name":"Department of Mycology, The Old Medical School, Thorseby Place, Leeds LS2 9JT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Barton","sequence":"additional","affiliation":[{"name":"Department of Mycology, The Old Medical School, Thorseby Place, Leeds LS2 9JT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Hobson","sequence":"additional","affiliation":[{"name":"Department of Mycology, The Old Medical School, Thorseby Place, Leeds LS2 9JT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00001432-200212000-00003","article-title":"Recent trends in the epidemiology of invasive mycoses","volume":"15","author":"Clark","year":"2002","journal-title":"Curr Opin Infect Dis"},{"key":"R2","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1128\/JCM.40.4.1298-1302.2002","article-title":"Epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of Iowa organisms study","volume":"40","author":"Diekema","year":"2002","journal-title":"J Clin Microbiol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1086\/520192","article-title":"Nosocomial bloodstream infections in United States hospitals: a three-year analysis","volume":"29","author":"Edmond","year":"1999","journal-title":"Clin Infect Dis"},{"key":"R4","article-title":"Rapid presumptive identification of Candida glabrata using BACTEC Lytic\/10 Anaerobic\/F Medium","volume-title":"In Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy","volume":"Abstract no. 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