{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:14:52Z","timestamp":1777522492361,"version":"3.51.4"},"reference-count":34,"publisher":"Microbiology Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:p>In addition to <jats:italic>Legionella pneumophila<\/jats:italic>, about 20 <jats:italic>Legionella<\/jats:italic> species have been documented as human pathogens. The majority of infections by non-<jats:italic>pneumophila<\/jats:italic> \n                  <jats:italic>Legionella<\/jats:italic> species occur in immunocompromised and splenectomized patients. Here, we report a case of \u2018classical\u2019 lobar pneumonia caused by <jats:italic>Legionella longbeachae<\/jats:italic> in a splenectomized patient receiving corticosteroids for chronic immune thrombocytopenia. Tests for <jats:italic>Legionella<\/jats:italic> antigen were negative. <jats:italic>L. longbeachae<\/jats:italic> was immediately detected in bronchoalveolar fluid by PCR and subsequently confirmed by culture on legionella-selective media. The features of Legionnaires' disease in immunocompromised patients with special emphasis on significance and detection of non-<jats:italic>pneumophila<\/jats:italic> species are reviewed.<\/jats:p>","DOI":"10.1099\/jmm.0.47556-0","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T17:08:55Z","timestamp":1203527335000},"page":"384-387","source":"Crossref","is-referenced-by-count":41,"title":["Legionnaires' disease in immunocompromised patients: a case report of Legionella longbeachae pneumonia and review of the literature"],"prefix":"10.1099","volume":"57","author":[{"given":"Philipp","family":"K\u00fcmpers","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Tiede","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Kirschner","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Girke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Ganser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich","family":"Peest","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1128\/JCM.00505-07","article-title":"A multicenter comparison of molecular methods for the detection of Legionella in sputum samples","volume":"45","author":"Bencini","year":"2007","journal-title":"J Clin Microbiol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1086\/342903","article-title":"Trends in legionnaires disease, 1980\u20131998: declining mortality and new patterns of diagnosis","volume":"35","author":"Benin","year":"2002","journal-title":"Clin Infect Dis"},{"key":"R3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1574-6968.1989.tb03617.x","article-title":"Rapid determination of bacterial ribosomal RNA sequences by direct sequencing of enzymatically amplified DNA","volume":"53","author":"Bottger","year":"1989","journal-title":"FEMS Microbiol Lett"},{"key":"R4","first-page":"IV1","article-title":"British Thoracic Society Standards of Care Committee","volume":"56 (Suppl. 4)","year":"2001","journal-title":"Thorax"},{"key":"R5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1099\/jmm.0.46453-0","article-title":"Detection and quantification of Legionella pneumophila DNA in serum: case reports and review of the literature","volume":"55","author":"Diederen","year":"2006","journal-title":"J Med Microbiol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1016\/j.jinf.2006.07.003","article-title":"Cavitary Legionella pneumonia in a patient with immunodeficiency due to Hyper-IgE syndrome","volume":"54","author":"Di Stefano","year":"2007","journal-title":"J Infect"},{"key":"R7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1164\/arrd.1983.127.1.121","article-title":"Pneumonia and multiple lung abscesses caused by dual infection with Legionella micdadei and Legionella pneumophila","volume":"127","author":"Dowling","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"R8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF01646415","article-title":"Community-acquired pneumonia caused by Legionella dumoffii in a patient with hairy cell leukemia","volume":"18","author":"Fang","year":"1990","journal-title":"Infection"},{"key":"R9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1399-3062.2004.00053.x","article-title":"Cavitary Legionella pneumonia in a liver transplant recipient","volume":"6","author":"Fraser","year":"2004","journal-title":"Transpl Infect Dis"},{"key":"R10","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s10096-003-1071-7","article-title":"Fatal case of community-acquired pneumonia caused by Legionella longbeachae in a patient with systemic lupus erythematosus","volume":"23","author":"Garcia","year":"2004","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R11","first-page":"179","article-title":"Legionella in two splenectomized patients","volume":"32","author":"Gorelik","year":"2004","journal-title":"Coincidence or causal relationship? Infection"},{"key":"R12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0025-6196(12)62667-6","article-title":"Legionella bozemanii pneumonia in an immunocompromised patient","volume":"63","author":"Jaeger","year":"1988","journal-title":"Mayo Clin Proc"},{"key":"R13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/clinids\/18.3.385","article-title":"Pulmonary infection due to Legionella cincinnatiensis in renal transplant recipients: two cases and implications for laboratory diagnosis","volume":"18","author":"Jernigan","year":"1994","journal-title":"Clin Infect Dis"},{"key":"R14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01584366","article-title":"Fatal Legionella longbeachae infection following heart transplantation","volume":"17","author":"Korman","year":"1998","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01644179","article-title":"Legionella longbeachae pneumonia in a patient splenectomized for hairy-cell leukemia","volume":"18","author":"Lang","year":"1990","journal-title":"Infection"},{"key":"R16","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","article-title":"Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults","volume":"44 (Suppl. 2)","author":"Mandell","year":"2007","journal-title":"Clin Infect Dis"},{"key":"R17","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1086\/386322","article-title":"Pneumonia and osteomyelitis due to Legionella longbeachae in a woman with systemic lupus erythematosus","volume":"38","author":"McClelland","year":"2004","journal-title":"Clin Infect Dis"},{"key":"R18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.7326\/0003-4819-94-6-739","article-title":"Legionella longbeachae species nova, another etiologic agent of human pneumonia","volume":"94","author":"McKinney","year":"1981","journal-title":"Ann Intern Med"},{"key":"R19","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1086\/342884","article-title":"Infection due to Legionella species other than L. pneumophila","volume":"35","author":"Muder","year":"2002","journal-title":"Clin Infect Dis"},{"key":"R20","first-page":"242","article-title":"The radiologic manifestations of Legionella pneumonia","volume":"2","author":"Muder","year":"1987","journal-title":"Semin Respir Infect"},{"key":"R21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1017\/S095026880600656X","article-title":"Does using potting mix make you sick? Results from a Legionella longbeachae case-control study in South Australia","volume":"135","author":"O'Connor","year":"2007","journal-title":"Epidemiol Infect"},{"key":"R22","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s10096-002-0813-2","article-title":"Legionnaires' disease contracted from patient homes: the coming of the third plague?","volume":"21","author":"Pedro-Botet","year":"2002","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.medmal.2007.03.015","article-title":"Factors associated with mortality in Legionnaires' disease, France, 2002\u20132004","volume":"37","author":"Poupard","year":"2007","journal-title":"Med Mal Infect"},{"key":"R24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/hon.2900090302","article-title":"Severe Legionella pneumophila infection in a patient with hairy cell leukemia in partial remission after alpha interferon treatment","volume":"9","author":"Radaelli","year":"1991","journal-title":"Hematol Oncol"},{"key":"R25","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/jac\/dkg191","article-title":"Legionnaires' disease: a rational approach to therapy","volume":"51","author":"Roig","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"R26","first-page":"128","article-title":"Legionella and immunosuppression","volume":"13","author":"Schlossberg","year":"1998","journal-title":"Semin Respir Infect"},{"key":"R27","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/clinids\/12.5.824","article-title":"Pneumonia due to Legionella micdadei in bone marrow transplant recipients","volume":"12","author":"Schwebke","year":"1990","journal-title":"Rev Infect Dis"},{"key":"R28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00000441-198705000-00005","article-title":"Legionella pneumophila lung abscess in a patient with systemic lupus erythematosus","volume":"293","author":"Senecal","year":"1987","journal-title":"Am J Med Sci"},{"key":"R29","first-page":"755","article-title":"Legionnaires's disease in a transplant recipient acquired from the patient's home: implications for management","volume":"74","author":"Singh","year":"2002","journal-title":"Transplantation"},{"key":"R30","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1378\/chest.113.5.1195","article-title":"Comparative study of the clinical presentation of Legionella pneumonia and other community-acquired pneumonias","volume":"113","author":"Sopena","year":"1998","journal-title":"Chest"},{"key":"R31","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1056\/NEJM199709043371006","article-title":"Legionellosis","volume":"337","author":"Stout","year":"1997","journal-title":"N Engl J Med"},{"key":"R32","first-page":"398","article-title":"The radiologic manifestations of Legionnaire's disease","volume":"117","author":"Tan","year":"2000","journal-title":"The Ohio Community-Based Pneumonia Incidence Study Group. Chest"},{"key":"R33","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1128\/JCM.25.11.2120-2122.1987","article-title":"Legionella birminghamensis sp. nov. isolated from a cardiac transplant recipient","volume":"25","author":"Wilkinson","year":"1987","journal-title":"J Clin Microbiol"},{"key":"R34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1086\/341087","article-title":"Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative survey","volume":"186","author":"Yu","year":"2002","journal-title":"J Infect Dis"}],"container-title":["Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.47556-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T05:19:54Z","timestamp":1601270394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmm\/10.1099\/jmm.0.47556-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,1]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmm.0.47556-0","relation":{},"ISSN":["0022-2615","1473-5644"],"issn-type":[{"value":"0022-2615","type":"print"},{"value":"1473-5644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,1]]}}}