{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:52:37Z","timestamp":1759009957835},"reference-count":29,"publisher":"Microbiology Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:p>Identification of<jats:italic>Neisseria meningitidis<\/jats:italic>PorA types remains important, as the PorA protein is a major immunogenic component of several meningococcal vaccines under development. In this study, 191<jats:italic>N. meningitidis<\/jats:italic>serogroup B isolates collected in Argentina through active laboratory-based surveillance from 2001 to 2003 were serosubtyped. Nucleotide sequences of the<jats:italic>porA<\/jats:italic>variable region 1 (VR1) and VR2 regions were determined in 52 non-serosubtypeable isolates. A substantial number of distinct VR types were identified, and a new VR2 variant from the P1.16 family was described. This is the first report describing PorA types in<jats:italic>N. meningitidis<\/jats:italic>serogroup B isolates in Argentina. Furthermore, the wide diversity of subtypes detected by serosubtyping and genosubtyping reveals the difficulty in designing a useful outer-membrane vaccine applicable in this country. A possible mechanism responsible for altered PorA expression was analysed in two PorA types.<\/jats:p>","DOI":"10.1099\/jmm.0.47631-0","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T17:08:55Z","timestamp":1203527335000},"page":"338-342","source":"Crossref","is-referenced-by-count":13,"title":["PorA types in Neisseria meningitidis serogroup B isolated in Argentina from 2001 to 2003: implications for the design of an outer membrane protein-based vaccine"],"prefix":"10.1099","volume":"57","author":[{"given":"Cecilia","family":"Sorhouet Pereira","sequence":"first","affiliation":[{"name":"Departamento de Bacteriolog\u00eda, Instituto Nacional de Enfermedades Infecciosas \u2013 ANLIS \u2018Dr Carlos G. Malbr\u00e1n\u2019, Av. 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