{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:21:28Z","timestamp":1792189288054,"version":"4.4.0"},"reference-count":32,"publisher":"Microbiology Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:p>\n                  <jats:italic>Candida albicans<\/jats:italic> is the most common candidal pathogen, causing serious systemic disease in immunocompromised patients. Azoles are widely applied and largely effective; however, they are generally fungistatic and clinically resistant isolates are emerging increasingly. The present study provided <jats:italic>in vitro<\/jats:italic> evidence using a chequerboard technique that amiodarone is strongly synergistic with azoles against resistant <jats:italic>C. albicans<\/jats:italic>, with mean fractional inhibitory concentration indices of 0.01 and high-percentage synergistic interactions of 1250\u200a%. A time\u2013kill study performed by both colony counting and a colorimetric reduction assay confirmed the synergistic interaction, with a \u22652 log<jats:sub>10<\/jats:sub> decrease in c.f.u. ml<jats:sup>\u22121<\/jats:sup> compared with the corresponding azoles alone. These results suggest the possibility of supplementing azoles with amiodarone to treat resistant <jats:italic>C. albicans<\/jats:italic> infections.<\/jats:p>","DOI":"10.1099\/jmm.0.47651-0","type":"journal-article","created":{"date-parts":[[2008,3,18]],"date-time":"2008-03-18T19:20:00Z","timestamp":1205868000000},"page":"457-462","source":"Crossref","is-referenced-by-count":39,"title":["Synergistic activity of azoles with amiodarone against clinically resistant Candida albicans tested by chequerboard and time\u2013kill methods"],"prefix":"10.1099","volume":"57","author":[{"given":"Qiongjie","family":"Guo","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Jinan 250014, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Hospital of Shandong University, Jinan 250012, PR China"},{"name":"School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Jinan 250014, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Cao","sequence":"additional","affiliation":[{"name":"The General Surgical Central Laboratory, Shandong Provincial Qianfoshan Hospital, Jinan 250014, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1128\/AAC.48.4.1335-1343.2004","article-title":"Potent synergistic in vitro interaction between nonantimicrobial membrane-active compounds and itraconazole against clinical isolates of Aspergillus fumigatus resistant to itraconazole","volume":"48","author":"Afeltra","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"R2","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1128\/AAC.01053-05","article-title":"Impact of antimicrobial dosing regimen on evolution of drug resistance in vivo: fluconazole and Candida albicans","volume":"50","author":"Andes","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"R3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jac\/41.1.59","article-title":"In-vitro interaction of terbinafine with amphotericin B, fluconazole and itraconazole against clinical isolates of Candida albicans","volume":"41","author":"Barchiesi","year":"1998","journal-title":"J Antimicrob Chemother"},{"key":"R4","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1128\/JCM.34.2.454-456.1996","article-title":"Direct identification and recognition of yeast species from clinical material by using albicans ID and CHROMagar Candida plates","volume":"34","author":"Baumgartner","year":"1996","journal-title":"J Clin Microbiol"},{"key":"R5","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts . 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