{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:13:50Z","timestamp":1771334030027,"version":"3.50.1"},"reference-count":26,"publisher":"Microbiology Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>Antimicrobial resistance in <jats:italic>Salmonella<\/jats:italic> spp. is of grave concern, more so in quinolone-resistant and extended-spectrum <jats:italic>\u03b2<\/jats:italic>-lactamase (ESBL)-producing isolates that cause complicated infections. The MIC of azithromycin, ciprofloxacin, cefixime, cefepime, ceftriaxone, gatifloxacin, imipenem, levofloxacin, meropenem and ofloxacin (E-test strip) and tigecycline and faropenem (agar dilution) against 210 <jats:italic>Salmonella<\/jats:italic> spp. was determined. MIC<jats:sub>90<\/jats:sub> (defined as the antimicrobial concentration that<jats:sup> <\/jats:sup>inhibited growth of 90\u200a% of the strains) of the carbapenems (imipenem and meropenem) for <jats:italic>Salmonella<\/jats:italic> Typhi and <jats:italic>Salmonella<\/jats:italic> Paratyphi A was 0.064\u2005\u03bcg\u2005ml<jats:sup>\u22121<\/jats:sup>. MIC<jats:sub>90<\/jats:sub> of faropenem was 0.25\u2005\u03bcg\u2005ml<jats:sup>\u22121<\/jats:sup> for <jats:italic>S<\/jats:italic>. Typhi, <jats:italic>S<\/jats:italic>. Paratyphi A and <jats:italic>Salmonella<\/jats:italic> Typhimurium. The MIC<jats:sub>90<\/jats:sub> of azithromycin for all <jats:italic>Salmonella<\/jats:italic> spp. ranged from 8 to 16\u2005\u03bcg\u2005ml<jats:sup>\u22121<\/jats:sup>. Tigecycline showed an MIC<jats:sub>90<\/jats:sub> of 2\u2005\u03bcg\u2005ml<jats:sup>\u22121<\/jats:sup> for <jats:italic>S<\/jats:italic>. Typhi, 1\u2005\u03bcg\u2005ml<jats:sup>\u22121<\/jats:sup> for <jats:italic>S.<\/jats:italic> Paratyphi A and 4\u2005\u03bcg\u2005ml<jats:sup>\u22121<\/jats:sup> for <jats:italic>S.<\/jats:italic> Typhimurium. We concluded that tigecycline and the carbapenems are likely to have roles in the final stage of treatment of quinolone-resistant and ESBL-producing multidrug-resistant salmonellae.<\/jats:p>","DOI":"10.1099\/jmm.0.47853-0","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T19:51:08Z","timestamp":1234295468000},"page":"337-341","source":"Crossref","is-referenced-by-count":31,"title":["Minimum inhibitory concentration of carbapenems and tigecycline against Salmonella spp."],"prefix":"10.1099","volume":"58","author":[{"given":"Malini R.","family":"Capoor","sequence":"first","affiliation":[{"name":"Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepthi","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra","family":"Posti","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Singhal","sequence":"additional","affiliation":[{"name":"New Drug Discovery, Ranbaxy Research Laboratories, Gurgaon, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monorama","family":"Deb","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pushpa","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parukutty","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Majeedia Hospital, Hamdard University, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/jac\/49.1.169","article-title":"Plasmid-mediated TEM-3 extended-spectrum \u03b2 -lactamase production in Salmonella typhimurium in Casablanca","volume":"49","author":"AitMhand","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"R2","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1128\/JCM.02351-06","article-title":"Comparative in vitro antimicrobial activity of tigecycline, a new glycylcycline compound, in freshly prepared medium and quality control","volume":"45","author":"Brown","year":"2007","journal-title":"J Clin Microbiol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/jac\/44.2.243","article-title":"Treatment of typhoid fever with azithromycin vs chloramphenicol in a randomized multicentre trial in India","volume":"44","author":"Butler","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"R4","first-page":"1170","article-title":"Narrowing therapeutic options in typhoid fever, India","volume":"37","author":"Capoor","year":"2006","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"R5","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1099\/jmm.0.47353-0","article-title":"In vitro activity of azithromycin, newer quinolones and cephalosporins in ciprofloxacin-resistant Salmonella causing enteric fever","volume":"56","author":"Capoor","year":"2007","journal-title":"J Med Microbiol"},{"key":"R6","article-title":"Performance Standards for Antimicrobial Susceptibility Testing , 17th Informational Supplement","volume":"26","year":"2006","journal-title":"CLSI Document M100\u2013S16"},{"key":"R7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/bmj.333.7563.353-b","article-title":"Fluoroquinolone resistance in Salmonella enterica serovar Typhi","volume":"333","author":"Cooke","year":"2006","journal-title":"BMJ"},{"key":"R8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1089\/mdr.2007.712","article-title":"Prevalence and characterization of extended-spectrum cephalosporin-resistant nontyphoidal Salmonellae isolates in adults in Saint Petersburg, Russia. 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