{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:13:13Z","timestamp":1768486393007,"version":"3.49.0"},"reference-count":9,"publisher":"Microbiology Society","issue":"2","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,19]]},"abstract":"<jats:sec sec-type=\"intro\">\n                  <jats:title>Introduction:<\/jats:title>\n                  <jats:p>\n                     <jats:italic>Rhodococcus<\/jats:italic> spp. have been implicated in a variety of infections in immunocompromised and immunocompetent hosts. <jats:italic>Rhodococcus equi<\/jats:italic> is responsible for the majority of reported cases, but <jats:italic>Rhodococcus erythropolis<\/jats:italic>, <jats:italic>Rhodococcusgordoniae<\/jats:italic> and <jats:italic>Rhodococcusruber<\/jats:italic> infections have been described. There are no prior reports of human infection with <jats:italic>Rhodococcus fascians<\/jats:italic>.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case presentation:<\/jats:title>\n                  <jats:p>We describe the unexpected finding of <jats:italic>R. fascians<\/jats:italic> in liver lesions incidentally noted at autopsy in an immunosuppressed patient status after bone-marrow transplant for acute lymphoblastic leukaemia who died of unrelated causes (septic shock due to <jats:italic>Clostridium difficile<\/jats:italic> colitis). At autopsy, an otherwise unremarkable liver contained several dozen well-demarcated sclerotic-appearing lesions measuring 0.1\u20130.3\u200acm in size. The absence of other bacterial or fungal DNA in the setting of histologically visible organisms argues against its presence as a contaminant and raises the consideration that <jats:italic>R. fascians<\/jats:italic> represents a human pathogen for the immunocompromised.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"conclusions\">\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Whether it represents the sole infectious agent responsible for the miliary lesions or a partially treated co-infection is impossible to determine, but our finding continues to reinforce the importance of molecular techniques in associating organisms with sites of infection and optimizing treatment of infectious diseases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1099\/jmmcr.0.005025","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T13:12:18Z","timestamp":1455714738000},"source":"Crossref","is-referenced-by-count":13,"title":["Rhodococcus fascians infection after haematopoietic cell transplantation: not just a plant pathogen?"],"prefix":"10.1099","volume":"3","author":[{"given":"Melissa C.","family":"Austin","sequence":"first","affiliation":[{"name":"Department of Pathology, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, MD 20889, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teal S.","family":"Hallstrand","sequence":"additional","affiliation":[{"name":"Departments of Pulmonary and Critical Care Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98105, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Hoogestraat","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98105, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Balmforth","sequence":"additional","affiliation":[{"name":"Department of Radiology, Swedish Medical Center, 5300 Tallman Ave NW, Seattle, WA 98107, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98105, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Butler-Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98105, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia C. S.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, 1100 Fairview ave N, Mailstop G7-910, Seattle, WA 98109, USA"},{"name":"Department of Anatomic Pathology, University of Washington, 1959 NE Pacific St, Seattle, WA 98105, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"jmmcr005025-Arnaout","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2014.919301"},{"key":"jmmcr005025-Bharadwaj1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00687.x"},{"key":"jmmcr005025-Francis1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-08-11-0215"},{"key":"jmmcr005025-Goethals1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.39.1.27"},{"key":"jmmcr005025-Horowitz1","first-page":"41","article-title":"Current status of allogeneic bone marrow transplantation","volume":"4","author":"Horowitz","year":"1990","journal-title":"Clin Transpl"},{"key":"jmmcr005025-Orr1","first-page":"97","article-title":"Colonization, biofilm formation and biodegradation of polyethylene by a strain of Rhodococcus ruber","volume":"65","author":"Orr","year":"2004","journal-title":"Appl Microbiol Biotechnol"},{"key":"jmmcr005025-Salipante1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06126-11"},{"key":"jmmcr005025-van1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2004.04.001"},{"key":"jmmcr005025-Young1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.11.044"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005025?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:38:49Z","timestamp":1702669129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,19]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4,19]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005025","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,19]]}}}