{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:46:37Z","timestamp":1762004797861},"reference-count":13,"publisher":"Microbiology Society","issue":"4","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,11]]},"abstract":"<jats:sec sec-type=\"intro\">\n                  <jats:title>Introduction:<\/jats:title>\n                  <jats:p>\n                     <jats:italic>Rhizopus<\/jats:italic> typically results in acute, aggressive and angioinvasive infection, particularly in immunosuppressed individuals. Risk factors include immunosuppression in haematologic malignancy, uncontrolled hyperglycemia, iron overload states, and older chelator agents such as deferoxamine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case Presentation:<\/jats:title>\n                  <jats:p>We describe a case of a 33-year-old female with transfusion-dependent beta thalassemia who was started on intravenous deferiprone therapy and subsequently presented with a retropharyngeal abscess. Despite intravenous broad spectrum antibiotics, she continued to deteriorate and developed aphasia. A CT scan of her head showed multiple hypodensities. Blood cultures grew <jats:italic>Rhizopus <\/jats:italic>species and a subsequent transesophageal echocardiogram showed a mass in the right atrium with a patent foramen ovale.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"conclusions\">\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Although deferiprone, a newer iron chelator agent, has antifungal properties <jats:italic>in vivo<\/jats:italic>, this case illustrates that angioinvasive <jats:italic>Rhizopus <\/jats:italic>infections can occur in patients treated with deferiprone.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1099\/jmmcr.0.005048","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T10:12:21Z","timestamp":1464689541000},"source":"Crossref","is-referenced-by-count":9,"title":["Angioinvasive mucormycosis and paradoxical stroke: a case report"],"prefix":"10.1099","volume":"3","author":[{"given":"Roxana","family":"Mititelu","sequence":"first","affiliation":[{"name":"McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Bourassa-Blanchette","sequence":"additional","affiliation":[{"name":"Department of Internal medicine, The Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116419"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409013310902"},{"key":"R4","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/0003-4975(94)00892-B","article-title":"Surgical treatment of impending paradoxical embolism through patent foramen ovale","volume":"59","author":"Caes","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"R5","first-page":"90","article-title":"Trapped thrombus in a patent foramen ovale","volume":"45","author":"Falk","year":"1997","journal-title":"Turk Kardiyol Dern Ars"},{"key":"R6","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1378\/chest.101.6.1733","article-title":"The clinical manifestations of cardiac mucormycosis","volume":"101","author":"Jackman","year":"1992","journal-title":"CHEST Journal"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(95)03415-H"},{"key":"R8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/archinte.158.5.438","article-title":"Impending paradoxical embolism","volume":"158","author":"Meacham","year":"1998","journal-title":"Arch Intern Med"},{"key":"R9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1378\/chest.09-0961","article-title":"Impending paradoxical embolism: systematic review of prognostic factors and treatment","volume":"137","author":"Myers","year":"2010","journal-title":"CHEST Journal"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.019"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1086\/432579"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr375"},{"key":"R1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ki.1989.301","article-title":"Effects of deferoxamine, feroxamine and iron on experimental mucormycosis (zygomycosis)","volume":"36","author":"Van Cutsem","year":"1989","journal-title":"Kidney Int"},{"key":"R13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/ajcp\/78.1.42","article-title":"Cardiac mucormycosis. A report of five patients and review of 14 previously reported cases","volume":"78","author":"Virmani","year":"1982","journal-title":"Am J Clin Pathol"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005048?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:40:10Z","timestamp":1702669210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7,11]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005048","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}