{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:33:09Z","timestamp":1790181189118,"version":"4.1.0"},"reference-count":22,"publisher":"Microbiology Society","issue":"4","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,11]]},"abstract":"<jats:sec sec-type=\"intro\">\n                  <jats:title>Introduction:<\/jats:title>\n                  <jats:p>Prior studies (predominantly from Europe) have demonstrated blood culture-negative endocarditis due to <jats:italic>Bartonella<\/jats:italic>. Our objective was to describe three cases of <jats:italic>Bartonella quintana<\/jats:italic> endocarditis identified within one year at a large hospital in Washington, DC, USA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case presentation:<\/jats:title>\n                  <jats:p> We constructed a descriptive case series from a retrospective review of medical records from April to December 2013 at an 800-bed urban hospital. All three patients (ages: 52, 55 and 57 years) were undomiciled\/homeless men with a history of alcoholism. Although they had negative blood cultures, echocardiography demonstrated aortic\/mitral valve perforation and regurgitation in one patient, aortic\/mitral valve vegetation with mitral regurgitation in the second patient, and aortic valve vegetation with regurgitation in the third patient. The patients had positive <jats:italic>Bartonella quintana<\/jats:italic> serum immunoglobulin G (IgG) with negative immunoglobulin M (IgM). PCR on DNA extracted from cardiac valves was positive for <jats:italic>Bartonella<\/jats:italic>, and DNA sequencing of PCR amplicons identified <jats:italic>Bartonella quintana<\/jats:italic>. Patients received treatment with doxycycline\/rifampin or doxycycline\/gentamicin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"conclusions\">\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p> Clinicians should consider <jats:italic>Bartonella<\/jats:italic> endocarditis as a differential diagnosis in patients who fit elements of the Duke Criteria, as well as having a history of homelessness and alcoholism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1099\/jmmcr.0.005049","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T16:58:39Z","timestamp":1463763519000},"source":"Crossref","is-referenced-by-count":19,"title":["Case series of Bartonella quintana blood culture-negative endocarditis in Washington, DC"],"prefix":"10.1099","volume":"3","author":[{"given":"Fisseha Y.","family":"Ghidey","sequence":"first","affiliation":[{"name":"Infectious Disease Section, MedStar Washington Hospital Center, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamuyimen","family":"Igbinosa","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, MedStar Washington Hospital Center, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Mills","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, MedStar Washington Hospital Center, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Lai","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, MedStar Washington Hospital Center, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Woods","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, MedStar Washington Hospital Center, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, MedStar Washington Hospital Center, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Fishbein","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, MedStar Washington Hospital Center, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Sampath","sequence":"additional","affiliation":[{"name":"Mayo Clinical Laboratory, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lowery","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, MedStar Washington Hospital Center, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Wortmann","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, MedStar Washington Hospital Center, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.8.3462-3468.2004"},{"key":"R2","article-title":"Differentiation of Bartonella species using restriction endonuclease analysis of PCR-amplified 16S rRNA genes","volume":"129","author":"Birtles","year":"1995","journal-title":"FEMS Microbiol Lett"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000158481.07569.8D"},{"key":"R4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-48351-6_2","article-title":"Applications and challenges of real-time PCR for the clinical microbiology laboratory","volume-title":"Rapid Cycle Real-Time PCR Methods and Applications","author":"Cockerill","year":"2002"},{"key":"R13","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/jcm.31.4.872-881.1993","article-title":"Rochalimaea elizabethae sp. nov. isolated from a patient with endocarditis","volume":"31","author":"Daly","year":"1993","journal-title":"J Clin Microbiol"},{"key":"R23","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1086\/342065","article-title":"Bartonellaquintana bacteremia among homeless people","volume":"36","author":"Foucalt","year":"2002","journal-title":"Clin Infect Dis"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200107000-00003"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1086\/653675"},{"key":"R8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/heart.89.3.258","article-title":"Blood culture negative endocarditis: analysis of 63 cases presenting over 25 years","volume":"89","author":"Lamas","year":"2003","journal-title":"Heart"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1086\/313753"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.3.1171-1176.2005"},{"key":"R11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1128\/CMR.9.3.273","article-title":"Bartonella (Rochalimaea) quintana infections","volume":"9","author":"Maurin","year":"1996","journal-title":"Clin Microbiol Rev"},{"key":"R12","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1128\/jcm.35.9.2283-2287.1997","article-title":"Serological cross-reactions between Bartonella and Chlamydia species: implications for diagnosis","volume":"35","author":"Maurin","year":"1997","journal-title":"J Clin Microbiol"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1086\/313890"},{"key":"R15","doi-asserted-by":"crossref","first-page":"646","DOI":"10.7326\/0003-4819-125-8-199610150-00004","article-title":"Diagnosis of 22 new cases of Bartonella endocarditis","volume":"125","author":"Raoult","year":"1996","journal-title":"Ann Intern Med"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.2.226"},{"key":"R16","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1128\/jb.173.5.1576-1589.1991","article-title":"Genotypic identification of rickettsiae and estimation of intraspecies sequence divergence for portions of two rickettsial genes","volume":"173","author":"Regnery","year":"1991","journal-title":"J Bacteriol"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.1921-1933.2004"},{"key":"R18","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1128\/jcm.31.3.692-694.1993","article-title":"Endocarditis caused by Rochalimaea quintana in a patient infected with human immunodeficiency virus","volume":"31","author":"Spach","year":"1993","journal-title":"J Clin Microbiol"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01095-07"},{"key":"R21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/jb.173.2.697-703.1991","article-title":"16S ribosomal DNA amplification for phylogenetic study","volume":"173","author":"Weisburg","year":"1991","journal-title":"J Bacteriol"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bb.15.060186.000525"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005049?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:39:06Z","timestamp":1702669146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7,11]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005049","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}