{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:56:46Z","timestamp":1773939406096,"version":"3.50.1"},"reference-count":21,"publisher":"Microbiology Society","issue":"4","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,11]]},"abstract":"<jats:sec sec-type=\"intro\">\n                  <jats:title>Introduction:<\/jats:title>\n                  <jats:p>\n                     <jats:italic>Nocardia<\/jats:italic> species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, <jats:italic>Nocardia<\/jats:italic> species may sometimes cause an infection disease in immunocompetent hosts. <jats:italic>Nocardia mexicana<\/jats:italic> infections are the least common and are very rare.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case presentation:<\/jats:title>\n                  <jats:p>Herein, we report the first case of a pulmonary infection with <jats:italic>N. mexicana<\/jats:italic> in a 61-year-old Japanese woman with a history of hyperlipidaemia and bronchiectasis and a 6-month history of non-productive hacking cough. A sample of bronchial lavage fluid obtained by bronchofiberscopy showed filamentous branching gram-positive rods and acid-fast filamentous branching rods, and a colony of suspected <jats:italic>Nocardia<\/jats:italic> was cultured. Based on 16S rRNA, <jats:italic>gyrB, <\/jats:italic>\n                     <jats:italic>rpoB<\/jats:italic>, <jats:italic>secA1<\/jats:italic> and <jats:italic>hsp65 <\/jats:italic>gene sequence analyses and biochemical and physiological properties, the strain was identified as <jats:italic>N. mexicana.<\/jats:italic> The strain was resistant to the antimicrobial agents amoxicillin-clavulanic acid, clarithromycin, minocycline, gentamycin, tobramycin, ciprofloxacin and trimethoprim-sulfamethoxazole. The patient was treated with biapenem followed by intravenous amikacin and oral linezolid.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"conclusions\">\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Despite its rarity, the species require attention owing to the existence of multidrug-resistant strains.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1099\/jmmcr.0.005054","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T16:11:38Z","timestamp":1465575098000},"source":"Crossref","is-referenced-by-count":12,"title":["First case report of pulmonary nocardiosis caused by Nocardia mexicana"],"prefix":"10.1099","volume":"3","author":[{"given":"Tomokazu","family":"kuchibiro","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Naga Municipal Hospital, 1282 Uchita, Kinokawa, Wakayama, 649-6414, 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