{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:13:27Z","timestamp":1702685607967},"reference-count":18,"publisher":"Microbiology Society","issue":"4","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,11]]},"abstract":"<jats:sec sec-type=\"intro\">\n                  <jats:title>Introduction:<\/jats:title>\n                  <jats:p> Dengue and meningococcal disease are caused by two different agents: a flavivirus and a Gram-negative bacterium, respectively. The first symptoms of both diseases can be indistinct and a rapid and accurate diagnosis is crucial, considering that both diseases are associated with high morbidity and mortality, representing a major public-health problem in Brazil.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case presentation:<\/jats:title>\n                  <jats:p> We report a fatal case of co-infection of dengue virus (DENV) and <jats:italic>Neisseria meningitidis<\/jats:italic> in a 54-year-old patient. The serum tested positive for DENV NS1 antigen, and <jats:italic>N. meningitidis<\/jats:italic> serogroup C was detected by <jats:italic>nspA<\/jats:italic>-PCR. Following the initial positive result for DENV infection, rRT-PCRwas performed and DENV-4 was confirmed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"conclusions\">\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p> Our report highlights the importance of accurate differential diagnosis during periods of high circulation of DENV, in order to provide adequate management and an improved outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1099\/jmmcr.0.005055","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T10:40:39Z","timestamp":1469616039000},"source":"Crossref","is-referenced-by-count":1,"title":["Fatal case of co-infection with dengue virus and Neisseria meningitidis during a dengue epidemic in the state of Rio de Janeiro, Brazil"],"prefix":"10.1099","volume":"3","author":[{"given":"Ivano","family":"de Filippis","sequence":"first","affiliation":[{"name":"National Institute for Quality Control of Health - INCQS, FIOCRUZ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Conrado","family":"Guerra Nunes","sequence":"additional","affiliation":[{"name":"Flavivirus Laboratory, Oswaldo Cruz Institution, FIOCRUZ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Ferreira","family":"de Andrade","sequence":"additional","affiliation":[{"name":"National Institute for Quality Control of Health - INCQS, FIOCRUZ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca de Santis","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Flavivirus Laboratory, Oswaldo Cruz Institution, FIOCRUZ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane Saraiva","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Flavivirus Laboratory, Oswaldo Cruz Institution, FIOCRUZ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itacirema de Oliveira","family":"Bezerra","sequence":"additional","affiliation":[{"name":"State Secretary of Health, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan Rocha Ferreira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases, FIOCRUZ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita Maria","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Flavivirus Laboratory, Oswaldo Cruz Institution, FIOCRUZ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria Bispo","family":"de Filippis","sequence":"additional","affiliation":[{"name":"Flavivirus Laboratory, Oswaldo Cruz Institution, FIOCRUZ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","article-title":"Perfil Epidemiol\u00f3gico da Meningite Brasil & Mundo","year":"2015"},{"key":"R2","article-title":"Informe epidemiol\u00f3gico da dengue \u2013 casos de dengue no Brasil, 1990 a 2014","year":"2016"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012393"},{"key":"R4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.diagmicrobio.2004.10.004","article-title":"Rapid detection of Neisseria meningitidis in cerebrospinal fluid by one-step polymerase chain reaction of the nspA gene","volume":"51","author":"de Filippis","year":"2005","journal-title":"Diagn Microbiol Infect Dis"},{"key":"R5","first-page":"50","article-title":"Neisseria meningitidis, pathogenetic mechanisms to overcome the human immune defences","volume":"53","author":"Gasparini","year":"2012","journal-title":"J Prev Med Hyg"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2010.07.016"},{"key":"R7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/jcm.30.3.545-551.1992","article-title":"Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction","volume":"30","author":"Lanciotti","year":"1992","journal-title":"J Clin Microbiol"},{"key":"R10","doi-asserted-by":"crossref","first-page":"bcr0220125804","DOI":"10.1136\/bcr.02.2012.5804","article-title":"Staphylococcus aureus pneumonia and dengue virus co-infection and review of implications of coinfection","volume":"2012","author":"Nagassar","year":"2012","journal-title":"BMJ Case Rep"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0220"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.3201\/eid1101.031091"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.4066\/AMJ.2014.2205"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61016-2"},{"key":"R13","article-title":"Boletim Epidemiol\u00f3gico 004\/2016. Governo do Estado do Rio de Janeiro","year":"2016"},{"key":"R16","first-page":"623","article-title":"Mortality from septic shock in a dengue infected patient: a case report","volume":"44","author":"Tsai","year":"2013","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00175-5"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003063"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(98)00061-4"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piu071"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005055?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:36:06Z","timestamp":1702668966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7,11]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005055","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}