{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:14:10Z","timestamp":1702685650953},"reference-count":21,"publisher":"Microbiology Society","issue":"5","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:sec sec-type=\"intro\">\n                  <jats:title>Introduction:<\/jats:title>\n                  <jats:p>Invasive pneumococcal disease is an uncommon and notifiable disease in Singapore. It is often associated with significant morbidity and mortality. We report a rare case of invasive pneumococcal bacteraemia due to parotitis in a patient with systemic sclerosis and secondary Sj\u00f6gren\u2019s syndrome. We also present a retrospective review of <jats:italic>Streptococcus pneumoniae<\/jats:italic> bacteraemia cases in Singapore General Hospital from January 2011 to April 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case presentation:<\/jats:title>\n                  <jats:p>A 59-year-old Malay lady with a history of systemic sclerosis with secondary Sj\u00f6gren\u2019s syndrome presented with fever and left parotid gland swelling. Clinical examination revealed poor salivary pooling and left parotid swelling without fluctuance. Ultrasound of the left parotid gland confirmed acute parotitis without evidence of abscess or sialolithiasis. Blood cultures were positive for <jats:italic>S. pneumoniae<\/jats:italic>. She was diagnosed to have invasive pneumococcal bacteraemia secondary to acute parotitis, and treated with intravenous benzylpenicillin with clearance of bacteraemia after 3 days. Upon discharge, her antibiotics were changed to intravenous ceftriaxone to facilitate outpatient parenteral antibiotic therapy for another 2 weeks. She responded favourably to antibiotics at follow-up, with no complications from the bacteraemia. A review of the microbiological records of the Singapore General Hospital revealed 116 cases of pneumococcal bacteraemia, most (80.3\u2009%) of which were due to pneumonia. None were due to parotitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"conclusions\">\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>\n                     <jats:italic>S. pneumoniae<\/jats:italic> parotitis and subsequent bacteraemia is rare. Prompt recognition of the disease and appropriate use of antibiotics are important. This case highlights that close communication between healthcare workers (microbiologist, rheumatologist and infectious disease specialist) is essential in ensuring good clinical outcomes in patients with a potentially fatal disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1099\/jmmcr.0.005068","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T10:12:22Z","timestamp":1474884742000},"source":"Crossref","is-referenced-by-count":0,"title":["Streptococcus pneumoniae bacteraemia due to parotitis in a patient with systemic sclerosis and secondary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1099","volume":"3","author":[{"given":"Irene Yuen Lin","family":"Yii","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie Bee Xian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren Weng Seng","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Singapore General Hospital, Singapore"},{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Duke-NUS Medical School, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.137216"},{"key":"R2","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/S0248-8663(97)80856-9","article-title":"Pneumococcal parotitis in human immunodeficiency virus infection","volume":"17","author":"Blanche","year":"1996","journal-title":"Rev Med Interne"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408544"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200301000-00006"},{"key":"R5","first-page":"1102","article-title":"Updated recommendations for prevention of invasive pneumococcal disease among adults using the 23-valent pneumococcal polysaccharide vaccine (PPSV23)","volume":"59","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"R6","first-page":"816","article-title":"Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine for adults with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"61","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"R8","article-title":"Performance Standards for Antimicrobial Susceptibility Testing; 26th Informational Supplement M100-S26","year":"2016"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1086\/338043"},{"key":"R10","first-page":"9","article-title":"Adult bacteremic pneumococcal pneumonia acquired in the community. A prospective study on 101 patients","volume":"63","author":"Gentile","year":"2003","journal-title":"Medicina"},{"key":"R11","first-page":"195","article-title":"Streptococcus pneumoniae acute suppurative parotitis in a patient with Sj\u00f6gren's syndrome","volume":"19","author":"Gomez-Rodrigo","year":"1990","journal-title":"J Otolaryngol"},{"key":"R12","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/00006454-199512000-00021","article-title":"Pneumococcal parotitis in a human immunodeficiency virus-infected child","volume":"14","author":"Hanekom","year":"1995","journal-title":"Pediatr Infect Dis J"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022678"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/627170"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6434a4"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700411"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081227"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000422.pub3"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1007\/BF00577751"},{"key":"R19","doi-asserted-by":"crossref","first-page":"bcr-2014-209082","DOI":"10.1136\/bcr-2014-209082","article-title":"Acute suppurative parotitis caused by Streptococcus pneumoniae in an HIV-infected man","volume":"2015","author":"Vinasco","year":"2015","journal-title":"BMJ Case Reports"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.206"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2011-200168"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005068?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T20:25:24Z","timestamp":1702671924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005068","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,1]]}}}