{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:33:25Z","timestamp":1792103605962,"version":"4.4.0"},"reference-count":16,"publisher":"Microbiology Society","issue":"1","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,31]]},"abstract":"<jats:p>\n                  <jats:bold>Background.<\/jats:bold> Pyogenic ventriculitis is a well-known complication of meningitis, brain abscesses and intraventricular drains. Primary pyogenic ventriculitis is a rare entity and few cases have been described so far. We report the first case of primary pyogenic ventriculitis in an adult caused by <jats:italic>Neisseria meningitidis<\/jats:italic> and present an overview of all reported adult primary pyogenic ventriculitis cases in the English literature.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods.<\/jats:bold> A PubMed search was performed using the terms ependymitis, ventricular empyema, pyocephalus and ventriculitis. Filter was set for adults and English. Articles in which pyogenic ventriculitis was a complication of well-known risk factors were excluded. A total of five cases of primary pyogenic ventriculitis were identified.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> There were seven adult patients. Only one patient showed signs of meningeal irritation. Four patients had positive blood cultures with <jats:italic>Escherichia coli<\/jats:italic> (one patient), methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (one patient), one patient was bacteraemic with <jats:italic>Enterococcus faecalis<\/jats:italic>, <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Peptostreptococcus<\/jats:italic> spp., and <jats:italic>N. meningitidis<\/jats:italic> (our patient). In four patients cerebrospinal fluid was sent for culture, which yielded methicillin-sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> (one patient), <jats:italic>Peptostreptococcus<\/jats:italic> spp. (one patient), <jats:italic>Streptococcus intermedius<\/jats:italic> (one patient, identified via 16S PCR) and <jats:italic>Listeria monocytogenes<\/jats:italic> (one patient). Cerebrospinal fluid cell count was determined in four patients and showed pleocytosis in all four cases. Ventricular drainage was performed in four patients. Five patients survived.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Discussion.<\/jats:bold> We report the first case of pyogenic ventriculitis caused by <jats:italic>N. meningitidis<\/jats:italic>. Primary pyogenic ventriculitis is a rare entity with various clinical presentations caused by various bacterial species. Treatment consists of adequate antimicrobial therapy, and ventricular drainage may be necessary.<\/jats:p>","DOI":"10.1099\/jmmcr.0.005078","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T11:12:34Z","timestamp":1482232354000},"source":"Crossref","is-referenced-by-count":26,"title":["Primary pyogenic ventriculitis caused by Neisseria meningitidis: case report and review of the literature"],"prefix":"10.1099","volume":"4","author":[{"given":"Firza","family":"Gronthoud","sequence":"first","affiliation":[{"name":"University Hospital of South Manchester, Southmoor Rd, Wythenshawe, Manchester M23 9LT1, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Hassan","sequence":"additional","affiliation":[{"name":"University Hospital of South Manchester, Southmoor Rd, Wythenshawe, Manchester M23 9LT2, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pippa","family":"Newton","sequence":"additional","affiliation":[{"name":"National Aspergillosis Centre, 2nd Floor, Education and Research Building Hospital, Manchester, Wythenshawe M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2006.05.018"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201148"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0b013e318142ce2c"},{"key":"R4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00004728-199003000-00021","article-title":"Cerebral ventriculitis: MR findings","volume":"14","author":"Barloon","year":"1990","journal-title":"J Comput Assist Tomogr"},{"key":"R5","first-page":"1510","article-title":"CT and MR imaging features of pyogenic ventriculitis","volume":"22","author":"Fukui","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0264-7"},{"key":"R7","article-title":"Meningococcal, chapter 22","volume-title":"The Green Book","year":"2016"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00007-10"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-008-9155-y"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0059-8"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-012-9784-z"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-016-0269-3"},{"key":"R13","article-title":"Unilateral pyogenic ventriculitis","volume":"18","author":"Lee","year":"1977","journal-title":"J Nucl Med"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1080\/02688690701246129"},{"key":"R15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2169\/internalmedicine.47.0509","article-title":"Listeria monocytogenes meningoencephalitis presenting with hydrocephalus and ventriculitis","volume":"47","author":"Ito","year":"2008","journal-title":"Intern Med"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-149"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005078?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T20:28:00Z","timestamp":1702672080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,31]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005078","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}