{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:21:23Z","timestamp":1769512883975,"version":"3.49.0"},"reference-count":25,"publisher":"Microbiology Society","issue":"4","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,12]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> Here, we present a case of polymicrobial anaerobic spondylodiscitis.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Case Presentation.<\/jats:bold> A forty-five year-old female patient was referred to a specialist orthopaedic hospital with an eight week history of back pain without fevers. X-ray imaging and magnetic resonance imaging showed acute osteomyelitis of the twelfth thoracic and first lumbar vertebrae. Prolonged enrichment cultures grew <jats:italic>Parvimonas micra<\/jats:italic> and <jats:italic>Fusobacterium nucleatum<\/jats:italic>, identified by matrix-assisted laser desorption ionisation-time of flight (MALDI-ToF) mass spectrometry (MS). The patient was successfully treated with six weeks of intravenous ertapenem and oral clindamycin.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> Anaerobic discitis is rare, and polymicrobial discitis is rarer still. A PubMed literature review revealed only seven cases of <jats:italic>F. nucleatum<\/jats:italic> discitis and only twelve cases of <jats:italic>P. micra<\/jats:italic> discitis; this includes only one other reported case of a polymicrobial discitis due to infection with both anaerobes. We emphasise the importance of prolonging enrichment culture and the use of fast yet accurate identification of anaerobes using MALDI-ToF MS in these infections.<\/jats:p>","DOI":"10.1099\/jmmcr.0.005092","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T13:15:13Z","timestamp":1493212513000},"source":"Crossref","is-referenced-by-count":15,"title":["A case of polymicrobial anaerobic spondylodiscitis due to Parvimonas micra and Fusobacterium nucleatum"],"prefix":"10.1099","volume":"4","author":[{"given":"Leanne M","family":"Cleaver","sequence":"first","affiliation":[{"name":"Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shara","family":"Palanivel","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Stanmore, London, UK"},{"name":"Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Mack","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Stanmore, London, UK"},{"name":"Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Warren","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Stanmore, London, UK"},{"name":"Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268807008850"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1086\/341916"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.08.004"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2012.04.003"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040181"},{"key":"R6","volume-title":"Investigation of Orthopaedic Implant Associated Infections","year":"2016"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000129928.03804.2A"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(13)70565-X"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.2.e26"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.06.012"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.09.001"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinmicnews.2011.07.002"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31827b4d61"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.08.025"},{"key":"R15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/jcm.24.4.633-635.1986","article-title":"Peptostreptococcal vertebral osteomyelitis","volume":"24","author":"Papasian","year":"1986","journal-title":"J Clin Microbiol"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1086\/313735"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/j.reumae.2014.01.003"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12877"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2015.07.006"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.06.002"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2015.05.013"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq303"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199103000-00019"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200007010-00010"},{"key":"R25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/CMR.11.1.81","article-title":"Gram-positive anaerobic cocci","volume":"11","author":"Murdoch","year":"1998","journal-title":"Clin Microbiol Rev"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005092?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T10:28:14Z","timestamp":1702636094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4,12]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005092","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]}}}