{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:57:31Z","timestamp":1777373851932,"version":"3.51.4"},"reference-count":26,"publisher":"Microbiology Society","issue":"5","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,3]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> Meningitis and endocarditis are common pathologies of <jats:italic>Streptococcus<\/jats:italic>\n                  <jats:italic>suis<\/jats:italic> infections in pigs and humans. <jats:italic>S. suis<\/jats:italic> serotype 9 strains contribute substantially to health problems in European pig production, and immune prophylaxis against this serotype is very difficult.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Case presentation.<\/jats:bold> We report the clinical course and histopathological picture of a 10-week-old growing pig following experimental intravenous infection with <jats:italic>S. suis<\/jats:italic> serotype 9. The piglet showed rapid onset of severe clinical signs of meningitis 11\u2009days post-intravenous challenge following prime-booster vaccination. Histopathological findings revealed a diffuse fibrinosuppurative leptomeningitis. Additionally, a polyphasic <jats:italic>endocarditis valvularis thromboticans<\/jats:italic> with numerous bacterial colonies was diagnosed. Bacteriological culture of the brain and the mitral valve confirmed association with the challenge strain. However, virulent serotype 2 and 9 strains were killed in the blood of this piglet <jats:italic>ex vivo<\/jats:italic> prior experimental infection.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> Endocarditis induced by <jats:italic>S. suis<\/jats:italic> infection might develop and persist despite the presence of high specific bactericidal activity in the blood. Severe leptomeningitis is a putative sequela of such an endocarditis.<\/jats:p>","DOI":"10.1099\/jmmcr.0.005093","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T15:18:42Z","timestamp":1493738322000},"source":"Crossref","is-referenced-by-count":9,"title":["Streptococcus suis serotype 9 endocarditis and subsequent severe meningitis in a growing pig despite specific bactericidal humoral immunity"],"prefix":"10.1099","volume":"4","author":[{"given":"Karoline","family":"Rieckmann","sequence":"first","affiliation":[{"name":"Institute for Bacteriology and Mycology, Centre for Infectious Diseases, Faculty of Veterinary Medicine, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Veterinary Medicine, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Moter","sequence":"additional","affiliation":[{"name":"Biofilmcenter, German Heart Institute Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph G","family":"Baums","sequence":"additional","affiliation":[{"name":"Institute for Bacteriology and Mycology, Centre for Infectious Diseases, Faculty of Veterinary Medicine, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Seydel","sequence":"additional","affiliation":[{"name":"Institute for Bacteriology and Mycology, Centre for Infectious Diseases, Faculty of Veterinary Medicine, University Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","first-page":"841","article-title":"Streptococcosis","volume-title":"Diseases of 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