{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:20:20Z","timestamp":1775575220886,"version":"3.50.1"},"reference-count":32,"publisher":"Microbiology Society","issue":"10","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,16]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> This is the first case report of septic abortion due to \u03b2-lactamase-negative ampicillin-resistant (BLNAR) non-typeable <jats:italic>Haemophilus influenzae<\/jats:italic> infection. In Japan, BLNAR <jats:italic>H. influenzae<\/jats:italic> is widespread and has become a clinical concern, especially in paediatrics and otolaryngology, but <jats:italic>H. influenzae<\/jats:italic> has not been previously recognized as a causative agent of obstetric or gynaecological infection.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Case presentation.<\/jats:bold> A 31-year-old pregnant woman presented at 17\u2009weeks and 6\u2009days of gestation with a high fever; she was admitted with a diagnosis of threatened premature delivery. Despite tocolytic treatment, she aborted spontaneously 2 h after admission and then entered septic shock. BLNAR <jats:italic>H. influenzae<\/jats:italic> was detected in both blood and vaginal cultures. Her condition gradually improved after several days of treatment with cefotaxime, and she was ultimately discharged without sequelae or complaints.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> Although penicillin with a \u03b2-lactamase inhibitor is currently recommended for the treatment of septic abortion, this combination will probably lead to treatment failure in the case of BLNAR <jats:italic>H. influenzae<\/jats:italic> infection. As this study reveals, <jats:italic>H. influenzae<\/jats:italic> can cause septic abortion; hence, future efforts should be undertaken to detect and therapeutically target this pathogen during pregnancy.<\/jats:p>","DOI":"10.1099\/jmmcr.0.005123","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T11:15:15Z","timestamp":1507806915000},"source":"Crossref","is-referenced-by-count":6,"title":["The first case report of septic abortion resulting from \u03b2-lactamase-negative ampicillin-resistant non-typeable Haemophilus influenzae infection"],"prefix":"10.1099","volume":"4","author":[{"given":"Hiroaki","family":"Baba","sequence":"first","affiliation":[{"name":"Department of Infection Control and Laboratory Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risako","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of 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