{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:04:42Z","timestamp":1762272282222},"reference-count":10,"publisher":"Microbiology Society","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:p><jats:bold>Introduction.<\/jats:bold><jats:italic>Campylobacter<\/jats:italic>is a common pathogen of the gastrointestinal tract, but invasive disease is rare.<jats:italic>Campylobacter fetus<\/jats:italic>can play a role in osteomyelitis, meningitis and joint infection and has a prediliction for the vascular endothelium, causing mycotic aneurysms, thrombophlebitis and endocarditis. Here we present a case of prosthetic valve endocarditis caused by<jats:italic>C. fetus<\/jats:italic>and a review of the literature.<\/jats:p><jats:p><jats:bold>Case presentation.<\/jats:bold>An 85-year-old woman with a tissue aortic valve replacement and atrial fibrillation was admitted to hospital with tonic-clonic seizures, right-sided hemiparesis, facial droop and hemianopia. Multiple cerebral emboli were seen on magnetic resonance imaging of the brain. Blood cultures grew<jats:italic>C. fetus<\/jats:italic>and an echocardiogram showed thickening and restricted movement of the aortic valve, a significant difference from an echocardiogram done 2 months before when the same organism was again isolated in blood cultures. She improved after treatment with 6 weeks of amoxicillin and 2 weeks of synergistic gentamicin for prosthetic valve endocarditis.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold>There have only been five previously reported cases of<jats:italic>C. fetus<\/jats:italic>prosthetic valve endocarditis and this is the only patient who presented as a stroke. The majority of surviving patients required replacement of the affected valve with only one other patient surviving in the absence of surgery. No guidelines exist on the optimum treatment of<jats:italic>C. fetus<\/jats:italic>endocarditis and this case reports adds to the growing literature on the appropriate management for this rare and potentially devastating disease.<\/jats:p>","DOI":"10.1099\/jmmcr.0.005147","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T16:13:40Z","timestamp":1523031220000},"source":"Crossref","is-referenced-by-count":9,"title":["Campylobacter fetus prosthetic valve endocarditis presenting as a stroke"],"prefix":"10.1099","volume":"5","author":[{"given":"Christina","family":"Petridou","sequence":"first","affiliation":[{"name":"Microbiology Department, Queen Alexandra Hospital, Southwick Hill Rd, Cosham, Portsmouth PO6 3LY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenka","family":"Strakova","sequence":"additional","affiliation":[{"name":"Microbiology Department, Queen Alexandra Hospital, Southwick Hill Rd, Cosham, Portsmouth PO6 3LY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruan","family":"Simpson","sequence":"additional","affiliation":[{"name":"Microbiology Department, Queen Alexandra Hospital, Southwick Hill Rd, Cosham, Portsmouth PO6 3LY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu085"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00631-13"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.3.443"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-212928"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000296"},{"key":"R6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7883\/yoken.JJID.2007.200","article-title":"A case of mitral endocarditis due to Campylobacter fetus subsp. fetus","volume":"60","author":"Wallet","year":"2007","journal-title":"Jpn J Infect Dis"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr450"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198806000-00028"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0699"},{"key":"R10","first-page":"584","article-title":"Campylobacter fetus as cause of prosthetic valve endocarditis","volume":"38","author":"Haruyama","year":"2011","journal-title":"Tex Heart Inst J"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005147?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T20:11:03Z","timestamp":1720210263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,1]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005147","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,1]]}}}