{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:40:58Z","timestamp":1756460458188},"reference-count":11,"publisher":"Microbiology Society","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold>\n                  <jats:italic>Ehrlichia<\/jats:italic> are obligate intracellular pathogens transmitted to vertebrates by ticks.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Case presentation.<\/jats:bold> We report the case of a 59-year-old man who presented to the University of Kentucky Albert B. Chandler Medical Center (Lexington, KY, USA) after being found fallen down in the woods. A lumbar puncture revealed what appeared to be bacterial meningitis, yet cerebrospinal fluid cultures, Gram stains and a meningitis\/encephalitis panel were inconclusive. However, an <jats:italic>Ehrlichia<\/jats:italic> DNA PCR of the blood resulted as being positive for <jats:italic>Ehrlichia chaffeensis<\/jats:italic> antibodies. The patient received a 14\u2009day course of doxycycline, and recovered from his multiple organ failure. The aetiology of the ehrlichial meningoencephalitis was likely transmission through a tick-bite, due to the patient\u2019s outdoor exposure.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> While it is rare to see <jats:italic>Ehrlichia<\/jats:italic> as a cause of meningitis, this illness can progress to severe multisystem disease with septic shock, meningoencephalitis or acute respiratory distress syndrome (ARDS). Those with compromised immunity are at a higher risk of developing the more severe form of the disease and have higher case fatality rates.<\/jats:p>","DOI":"10.1099\/jmmcr.0.005162","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T12:12:46Z","timestamp":1532693566000},"source":"Crossref","is-referenced-by-count":9,"title":["Ehrlichiosis presenting as severe sepsis and meningoencephalitis in an immunocompetent adult"],"prefix":"10.1099","volume":"5","author":[{"given":"Stephanie L.","family":"Buzzard","sequence":"first","affiliation":[{"name":"1\u200bDepartment of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany D.","family":"Bissell","sequence":"additional","affiliation":[{"name":"1\u200bDepartment of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY, USA"},{"name":"2\u200bDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa L.","family":"Thompson Bastin","sequence":"additional","affiliation":[{"name":"2\u200bDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA"},{"name":"1\u200bDepartment of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","article-title":"Ehrlichiosis","year":"2016"},{"key":"R2","first-page":"375","article-title":"Ehrlichia chaffeensis: a prevalent, life-threatening, emerging pathogen","volume":"115","author":"Walker","year":"2004","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v3.i5.430"},{"key":"R4","article-title":"Ehrlichiosis","author":"Baker","year":"2015"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0480-x"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.3.1786"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1099\/jmmcr.0.000349"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1177\/1941874415596743"},{"key":"R9","article-title":"Aseptic meningitis secondary to Ehrlichia chaffeensis","volume":"10","author":"Ugbarugba","year":"2015","journal-title":"J Hosp Med"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.3109\/00365549609037953"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318168da1d"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005162?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T13:17:57Z","timestamp":1702646277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005162","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}