{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:02:56Z","timestamp":1773813776875,"version":"3.50.1"},"reference-count":10,"publisher":"Microbiology Society","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> Guillain Barr\u00e9 Syndrome (GBS) has rarely been associated with tuberculosis and has been previously reported after Bacille Calmette Gu\u00e9rin (BCG) vaccination, but we report an association of GBS with intra-vesical BCG instillations followed by the clinical picture of disseminated BCGosis.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Case presentation.<\/jats:bold> A 68-year-old man with bladder carcinoma had a transurethral tumour resection followed by repeated BCG instillations. Catheterization for his eighth dose was traumatic, causing frank haematuria. Ten days later he presented with fevers, myalgia and dyspnoea. Chest X-ray on admission showed micronodular shadowing and a computed tomography scan showed miliary changes in the lungs. Disseminated BCGosis infection was suspected and his symptoms did improve after starting rifamipicin, isoniazid and ethambutol. Over 2\u2009weeks post-admission he developed an unsteady gait, reduced pin-prick sensation below both knees and fingertips, reduced proprioception in both toes and ankles, with absent reflexes in his lower limbs and diminished reflexes in his upper limbs. Nerve conduction studies showed a purely demyelinating sensori-motor peripheral neuropathy in upper and lower limbs, characteristic of GBS.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> To our knowledge this is the first case report of GBS following bladder instillation of BCG. Given the millions of cases of tuberculosis and millions of doses of administered BCG, GBS must be a very rare adverse effect.<\/jats:p>","DOI":"10.1099\/jmmcr.0.005164","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T16:12:41Z","timestamp":1534781561000},"source":"Crossref","is-referenced-by-count":8,"title":["Guillain Barr\u00e9 syndrome associated with bladder instillation of Bacille Calmette Gu\u00e9rin (BCG)"],"prefix":"10.1099","volume":"5","author":[{"given":"Karmel","family":"Webb","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Nottingham University Hospitals City Campus, Nottingham NG5 1PB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradhib","family":"Venkatesan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nottingham University Hospitals City Campus, Nottingham NG5 1PB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.59.694.516"},{"key":"R2","first-page":"655","article-title":"AMSAN variant of Guillain Barre syndrome progressing to chronic inflammatory demyelinating polyneuropathy in a patient with Marfan's syndrome and pulmonary tuberculosis","volume":"60","author":"Soehardy","year":"2005","journal-title":"Med J Malaysia"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1186\/1755-7682-3-15"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01366.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-01-2012-5484"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201403-101LE"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3798(99)90983-2"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67665-9"},{"key":"R9","first-page":"377","article-title":"Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis","volume":"40","author":"Chong","year":"2007","journal-title":"J Microbiol Immunol Infect"},{"key":"R10","article-title":"Onco-TICE- summary of product characteristics"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005164?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T12:31:56Z","timestamp":1702643516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005164","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]}}}