{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:16:31Z","timestamp":1702685791766},"reference-count":12,"publisher":"Microbiology Society","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold>\n                  <jats:italic>Enterococcus faecium<\/jats:italic> is a commensal organism commonly colonizing the human gastrointestinal tract. Although it is generally a non-virulent organism, <jats:italic>E. faecium<\/jats:italic> can cause significant morbidity and mortality due to its inherent and acquired resistances to commonly used antimicrobials. Patients who are immunosuppressed are particularly vulnerable.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Case presentation.<\/jats:bold> A 65\u201375-year-old patient with a history of an orthotopic liver transplant for hepatitis C infection and diabetes was re-admitted to the hospital with abdominal pain and fever. The patient had several recent admissions related to the presentation reported here, which included treatment with a prolonged course of broad-spectrum antibiotics. The patient was found to have a recurrent liver abscess and blood cultures grew vancomycin-resistant <jats:italic>E. faecium<\/jats:italic>, non-susceptible to all tested agents: ampicillin, penicillin, vancomycin, daptomycin and linezolid. The patient was started initially on chloramphenicol intravenously while awaiting additional susceptibility testing, which ultimately revealed chloramphenicol non-susceptibility. Tigecycline was started but the patient ultimately decided to pursue hospice care.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> Multi-drug-resistant organisms are increasingly being recognized and are associated with poorer outcomes, particularly in immunosuppressed patients. We describe a particularly resistant organism and discuss potential therapeutic options.<\/jats:p>","DOI":"10.1099\/jmmcr.0.005172","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T14:15:24Z","timestamp":1545315324000},"source":"Crossref","is-referenced-by-count":3,"title":["Multi-drug-resistant Enterococcus faecium bacteraemia in a liver transplant recipient"],"prefix":"10.1099","volume":"6","author":[{"given":"Nathan A.","family":"Summers","sequence":"first","affiliation":[{"name":"1\u200bDivision of Infectious Diseases, Department of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gharbin","sequence":"additional","affiliation":[{"name":"2\u200bDepartment of Global Health, Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Friedman-Moraco","sequence":"additional","affiliation":[{"name":"1\u200bDivision of Infectious Diseases, Department of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Marshall","family":"Lyon","sequence":"additional","affiliation":[{"name":"1\u200bDivision of Infectious Diseases, Department of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Lutgring","sequence":"additional","affiliation":[{"name":"1\u200bDivision of Infectious Diseases, Department of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2761"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.228"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12099"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03214.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"R6","volume-title":"FDA Warns of Increased Risk of Death with IV Antibacterial Tygacil (Tigecycline) and Approves New Boxed Warning.","year":"2013"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir924"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1086\/587896"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00678-12"},{"key":"R10","first-page":"44n","article-title":"Chloramphenicol toxicity: 25 years of research","volume":"87","author":"Yunis","year":"1989","journal-title":"Am J Med"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1086\/502365"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.4.869"}],"container-title":["JMM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005172?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T06:29:09Z","timestamp":1702621749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.005172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jmmcr.0.005172","relation":{},"ISSN":["2053-3721"],"issn-type":[{"value":"2053-3721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]}}}