{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:31:40Z","timestamp":1775709100058,"version":"3.50.1"},"reference-count":14,"publisher":"Microbiology Society","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"\n Introduction.<\/jats:bold>\n \n \n Nocardia nova<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> complex has been associated with infections in both immunocompetent and immunocompromised patients. Infection can be localized or disseminated, affecting skin and soft tissues, the respiratory system, bones and joints, the circulatory system and especially the central nervous system. Ocular infections such as keratitis, scleritis, conjunctivitis, dacryocystitis, orbital cellulitis and endophthalmitis due to \n \n Nocardia<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> spp. are infrequently reported, and usually described after penetrating corneal trauma or ocular contact with plants and soils.<\/jats:p>\n \n Case presentation.<\/jats:bold> An immunocompetent male presented with a history of penetrating ocular trauma that had evolved to infectious endophthalmitis, which was refractory to different antibiotic treatments. No micro-organisms were isolated from repeated conjunctival smear and corneal scraping cultures between the ocular trauma (August 2014) and the endophthalmitis diagnosis (November 2015). After this period, \n \n N. nova<\/jats:ext-link>\n <\/jats:named-content> sensu stricto<\/jats:italic> was isolated in aqueous humour aspirate. Treatment was adjusted and clinical improvement was obtained after an adequate microbiological procedure, including an optimal sampling and an antimicrobial-susceptibility testing report.<\/jats:p>\n \n Conclusion.<\/jats:bold>\n \n \n Nocardia<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> identification to the species level and performance of antimicrobial-susceptibility tests are both essential tools for treatment adjustment and clinical improvement.<\/jats:p>","DOI":"10.1099\/jmmcr.0.005175","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T18:12:49Z","timestamp":1550599969000},"source":"Crossref","is-referenced-by-count":12,"title":["Post-traumatic endophthalmitis caused by Nocardia nova"],"prefix":"10.1099","volume":"6","author":[{"given":"Jes\u00fas","family":"Rodr\u00edguez-Lozano","sequence":"first","affiliation":[{"name":"1\u200bDepartament of Microbiology, University Hospital Marqu\u00e9s de Valdecilla - IDIVAL, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Armi\u00f1anzas Castillo","sequence":"additional","affiliation":[{"name":"2\u200bDepartment of Infectious Diseases, University Hospital Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Ruiz de Alegr\u00eda Puig","sequence":"additional","affiliation":[{"name":"1\u200bDepartament of Microbiology, University Hospital Marqu\u00e9s de Valdecilla - IDIVAL, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Ventosa Ayarza","sequence":"additional","affiliation":[{"name":"3\u200bDepartment of Ophthalmology, University Hospital Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmen","family":"Fari\u00f1as","sequence":"additional","affiliation":[{"name":"2\u200bDepartment of Infectious Diseases, University Hospital Marqu\u00e9s de Valdecilla, Santander, Spain"},{"name":"4\u200bDepartment of Medicine and Psychiatry, University of Cantabria, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Ag\u00fcero","sequence":"additional","affiliation":[{"name":"1\u200bDepartament of Microbiology, University Hospital Marqu\u00e9s de Valdecilla - IDIVAL, Santander, Spain"},{"name":"5\u200bDepartment of Molecular Biology, University of Cantabria, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Calvo","sequence":"additional","affiliation":[{"name":"1\u200bDepartament of Microbiology, University Hospital Marqu\u00e9s de Valdecilla - IDIVAL, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46774-0"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000143"},{"key":"R3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1128\/jcm.35.4.847-852.1997","article-title":"Comparison of agar dilution, broth microdilution, disk diffusion, E-test, and BACTEC radiometric methods for antimicrobial susceptibility testing of clinical isolates of the Nocardia asteroides complex","volume":"35","author":"Ambaye","year":"1997","journal-title":"J Clin Microbiol"},{"key":"R4","volume-title":"Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes; 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