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Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome analysis and k-mer based analysis. Core and accessory genome analyses found no association with either of the two clinical groups. In this study, the genome sequences of <jats:italic>S. aureus<\/jats:italic> bloodstream isolates did not discriminate between bacteraemia and infective endocarditis. Based on our study and the current literature, it is not convincing that a specific <jats:italic>S. aureus<\/jats:italic> genotype is clearly associated to infective endocarditis in patients with <jats:italic>S. aureus<\/jats:italic> bacteraemia.<\/jats:p>","DOI":"10.1099\/mgen.0.000138","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T15:12:40Z","timestamp":1511190760000},"source":"Crossref","is-referenced-by-count":22,"title":["Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis"],"prefix":"10.1099","volume":"3","author":[{"given":"Berit","family":"Lilje","sequence":"first","affiliation":[{"name":"1\u200bDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus Vedby","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"2\u200bDepartment of Cardiology, 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