{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T20:32:56Z","timestamp":1722371576452},"reference-count":51,"publisher":"Microbiology Society","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:p>\n                  <jats:italic>Neisseria meningitidis<\/jats:italic> serogroup B (MnB) was responsible for two independent meningococcal disease outbreaks at universities in the USA during 2013. The first at University A in New Jersey included nine confirmed cases reported between March 2013 and March 2014. The second outbreak occurred at University B in California, with four confirmed cases during November 2013. The public health response to these outbreaks included the approval and deployment of a serogroup B meningococcal vaccine that was not yet licensed in the USA. This study investigated the use of whole-genome sequencing(WGS) to examine the genetic profile of the disease-causing outbreak isolates at each university. Comparative WGS revealed differences in evolutionary patterns between the two disease outbreaks. The University A outbreak isolates were very closely related, with differences primarily attributed to single nucleotide polymorphisms\/insertion-deletion (SNP\/indel) events. In contrast, the University B outbreak isolates segregated into two phylogenetic clades, differing in large part due to recombination events covering extensive regions (&gt;30\u2009kb) of the genome including virulence factors. This high-resolution comparison of two meningococcal disease outbreaks further demonstrates the genetic complexity of meningococcal bacteria as related to evolution and disease virulence.<\/jats:p>","DOI":"10.1099\/mgen.0.000155","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T13:12:47Z","timestamp":1522847567000},"source":"Crossref","is-referenced-by-count":2,"title":["Distinct evolutionary patterns of Neisseria meningitidis serogroup B disease outbreaks at two universities in the USA"],"prefix":"10.1099","volume":"4","author":[{"given":"Li","family":"Hao","sequence":"first","affiliation":[{"name":"1\u200bVaccine Research & Development, Pfizer Inc, 401 N. Middletown Rd, Pearl River, NY 10965, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T. 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