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Antimicrobial treatment, most commonly with fluoroquinolones, is currently recommended for <jats:italic>Shigella<\/jats:italic> infections to alleviate symptoms and control disease transmission. Resistance to fluoroquinolones has emerged in differing <jats:italic>Shigella<\/jats:italic> species (<jats:italic>S. dysenteriae<\/jats:italic>, <jats:italic>flexneri<\/jats:italic> and <jats:italic>sonnei<\/jats:italic>) since the turn of the 21st century, originating in endemic areas, and latterly spreading into non-endemic regions. Despite occurring independently, the emergence of fluoroquinolone resistance in these different <jats:italic>Shigella<\/jats:italic> species shares striking similarities regarding their epidemiology and resistance mechanisms. Here, we review and discuss the current epidemiology of fluoroquinolone-resistant <jats:italic>Shigella<\/jats:italic> species, particularly in the light of recent genomic insights.<\/jats:p>","DOI":"10.1099\/mgen.0.000171","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T14:12:49Z","timestamp":1522332769000},"source":"Crossref","is-referenced-by-count":15,"title":["Out of Asia: the independent rise and global spread of fluoroquinolone-resistant Shigella"],"prefix":"10.1099","volume":"4","author":[{"given":"Hao","family":"Chung The","sequence":"first","affiliation":[{"name":"Enteric Infections, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Baker","sequence":"additional","affiliation":[{"name":"Enteric Infections, Oxford University Clinical Research Unit, Ho Chi Minh City, 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