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Whereas typhoid fever is most prevalent in South and South-East Asia, non-typhoidal salmonellosis is prevalent across the globe and associated with a mild gastroenteritis. By contrast, invasive non-typhoidal <jats:italic>Salmonella<\/jats:italic> cause bloodstream infections associated with high mortality, particularly in sub-Saharan Africa. Most <jats:italic>Salmonella<\/jats:italic> strains from clinical sources are resistant to first-line antibiotics, with FQs now being the antibiotic of choice for treatment of invasive <jats:italic>Salmonella<\/jats:italic> infections. However, FQ resistance is increasingly being reported in <jats:italic>Salmonella<\/jats:italic>, and multiple molecular mechanisms are already described. Whole-genome sequencing (WGS) is becoming more frequently used to analyse bacterial genomes for antibiotic-resistance markers, and to understand the phylogeny of bacteria in relation to their antibiotic-resistance profiles. 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