{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:42:20Z","timestamp":1791618140840,"version":"4.3.4"},"reference-count":40,"publisher":"Microbiology Society","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"FONDECYT","award":["1161161"],"award-info":[{"award-number":["1161161"]}]},{"name":"FONDECYT","award":["3190524"],"award-info":[{"award-number":["3190524"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:p>\n                    <jats:italic>\n                      <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.2947\" xlink:type=\"simple\">Vibrio cholerae<\/jats:ext-link>\n                      <\/jats:named-content>\n                    <\/jats:italic>\n                    is a human pathogen, which is transmitted by the consumption of contaminated food or water.\n                    <jats:italic>\n                      <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.2947\" xlink:type=\"simple\">V. cholerae<\/jats:ext-link>\n                      <\/jats:named-content>\n                    <\/jats:italic>\n                    strains belonging to the serogroups O1 and O139 can cause cholera outbreaks and epidemics, a severe life-threatening diarrheal disease. In contrast, serogroups other than O1 and O139, denominated as non-O1\/non-O139, have been mainly associated with sporadic cases of moderate or mild diarrhea, bacteremia and wound infections. Here we investigated the virulence determinants and phylogenetic origin of a non-O1\/non-O139\n                    <jats:italic>\n                      <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.2947\" xlink:type=\"simple\">V. cholerae<\/jats:ext-link>\n                      <\/jats:named-content>\n                    <\/jats:italic>\n                    strain that caused a gastroenteritis outbreak in Santiago, Chile, 2018. We found that this outbreak strain lacks the classical virulence genes harboured by O1 and O139 strains, including the cholera toxin (CT) and the toxin-coregulated pilus (TCP). However, this strain carries genomic islands (GIs) encoding Type III and Type VI secretion systems (T3SS\/T6SS) and antibiotic resistance genes. Moreover, we found these GIs are wide distributed among several lineages of non-O1\/non-O139 strains. Our results suggest that the acquisition of these GIs may enhance the virulence of non-O1\/non-O139 strains that lack the CT and TCP-encoding genes. Our results highlight the pathogenic potential of these\n                    <jats:italic>\n                      <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.2947\" xlink:type=\"simple\">V. cholerae<\/jats:ext-link>\n                      <\/jats:named-content>\n                    <\/jats:italic>\n                    strains.\n                  <\/jats:p>","DOI":"10.1099\/mgen.0.000340","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T12:13:32Z","timestamp":1582200812000},"source":"Crossref","is-referenced-by-count":28,"title":["Genomic characterization of the non-O1\/non-O139 Vibrio cholerae strain that caused a gastroenteritis outbreak in Santiago, Chile, 2018"],"prefix":"10.1099","volume":"6","author":[{"given":"M\u00f3nica","family":"Arteaga","sequence":"first","affiliation":[{"name":"Servicio de Urgencia Infantil, Hospital Cl\u00ednico de la Universidad de Chile \u201cDr. Jos\u00e9 Joaqu\u00edn Aguirre\u201d, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Velasco","sequence":"additional","affiliation":[{"name":"Servicio de Urgencia Infantil, Hospital Cl\u00ednico de la Universidad de Chile \u201cDr. Jos\u00e9 Joaqu\u00edn Aguirre\u201d, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Servicio de Urgencia Infantil, Hospital Cl\u00ednico de la Universidad de Chile \u201cDr. Jos\u00e9 Joaqu\u00edn Aguirre\u201d, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-4845","authenticated-orcid":false,"given":"Maricel","family":"Vidal","sequence":"additional","affiliation":[{"name":"Laboratorio de Salud P\u00fablica Ambiental y Laboral, Secretar\u00eda Regional Ministerial de Salud Regi\u00f3n Metropolitana, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Arellano","sequence":"additional","affiliation":[{"name":"Programa de Microbiolog\u00eda y Micolog\u00eda, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Silva","sequence":"additional","affiliation":[{"name":"Servicio de Laboratorio Cl\u00ednico, Hospital Cl\u00ednico de la Universidad de Chile \u201cDr. Jos\u00e9 Joaqu\u00edn Aguirre\u201d, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-7158","authenticated-orcid":false,"given":"Leandro J.","family":"Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Instituto Milenio de Inmunolog\u00eda e Inmunoterapia, Facultad de Medicina, Universidad de Chile, Santiago, Chile"},{"name":"Programa de Inmunolog\u00eda, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Vidal","sequence":"additional","affiliation":[{"name":"Programa de Microbiolog\u00eda y Micolog\u00eda, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile"},{"name":"Instituto Milenio de Inmunolog\u00eda e Inmunoterapia, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Montero","sequence":"additional","affiliation":[{"name":"Programa de Inmunolog\u00eda, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile"},{"name":"Programa de Microbiolog\u00eda y Micolog\u00eda, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1903.121156"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065342"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02026-08"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1346-3"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao2136"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-10182019000300392"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2017.04.021"},{"key":"R8","article-title":"Departamento de Epidemiolog\u00eda. 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