{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:06:31Z","timestamp":1784325991641,"version":"3.55.0"},"reference-count":47,"publisher":"Microbiology Society","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Program on Key Research Project of China","award":["2017YFC1600103; 2018YFD0500501"],"award-info":[{"award-number":["2017YFC1600103; 2018YFD0500501"]}]},{"name":"National Program on Key Research Project of China","award":["2019YFE0103900"],"award-info":[{"award-number":["2019YFE0103900"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:p>\n                  <jats:italic>\n                     <jats:named-content content-type=\"genus\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3291\" xlink:type=\"simple\">Salmonella<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> is composed of a wide variety of serovars, causing human self-limited gastrointestinal illnesses or invasive infections. Invasive non-typhoidal <jats:italic>\n                     <jats:named-content content-type=\"genus\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3291\" xlink:type=\"simple\">Salmonella<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> (iNTS) is well documented, with high mortality for children and immunocompromised adults in sub-Saharan Africa and has recently been reported in Southeast Asia. However, iNTS in China remains unknown. In May 2019, a case of invasive infection caused by <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.11017\" xlink:type=\"simple\">Salmonella enterica<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> serovar Uzaramo (<jats:italic>S<\/jats:italic>. Uzaramo) was reported for the first time in China. Phylogenomic analysis was performed by genomic sequencing the available contextualized isolates, which separated the two Chinese strains into different sublineages. Both phenotypic and genomic characterization demonstrated that the <jats:italic>S<\/jats:italic>. Uzaramo isolates showed in general low antimicrobial resistance potential, except one isolated from lake-water in China. Additional comparative genomic analysis and <jats:italic>Caenorhabditis elegans<\/jats:italic> killing assays suggested a unique combination of virulence factors, including typhoid toxin and <jats:italic>tcf<\/jats:italic> fimbrial adhesin, which might play a role in the invasive infection. This study highlights that the transparency of global surveillance genomic data could accelerate understanding of virulence and antimicrobial resistance makeup of a previously unknown threat.<\/jats:p>","DOI":"10.1099\/mgen.0.000401","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T17:31:48Z","timestamp":1593797508000},"source":"Crossref","is-referenced-by-count":36,"title":["Genomic characterization of Salmonella Uzaramo for human invasive infection"],"prefix":"10.1099","volume":"6","author":[{"given":"Xuebin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Microbiology Laboratory, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Panzhihua Center for Disease Control and Prevention, Panzhihua 617000, PR 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