{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:57:52Z","timestamp":1775815072927,"version":"3.50.1"},"reference-count":48,"publisher":"Microbiology Society","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"Research into the lower urinary tract (LUT) microbiota has primarily focused on its relationship to LUT symptoms (LUTS), taking snapshots of these communities in individuals with and without LUTS. While certain bacterial taxa have been associated with LUTS, or the lack thereof, the temporal dynamics of this community were largely unknown. Recently, we conducted a longitudinal study and found that vaginal intercourse resulted in a shift in species richness and diversity within the LUT microbiota. This is particularly relevant as frequent vaginal intercourse is a major risk factor for urinary tract infection (UTI) in premenopausal women (Aydin et al. Int Urogynecol J<\/jats:italic> 2015;26:795\u2013804). To further investigate the relationship between vaginal intercourse and LUT microbiota, here we present the results of a 3\u2009week study in which daily urogenital specimens were collected from a female participant and her male sexual partner. Consistent with our previous findings, the LUT microbiota changed after vaginal intercourse, most notably a high abundance of \n \n Streptococcus mitis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> was observed post-coitus. We isolated and sequenced \n \n S. mitis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> from both sexual partners finding that: (i) the \n \n S. mitis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> isolates from the female partner\u2019s urogenital tract were genomically similar throughout the duration of the study, and (ii) they were related to one isolate from the male partner\u2019s oral cavity collected at the end of the study, suggesting transmission between the two individuals. We hypothesize that blooms in \n \n S. mitis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> after vaginal intercourse may play a role in coitus-related UTI. We found that a \n \n S. mitis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> isolate, in contrast to a \n \n Lactobacillus jensenii<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> isolate displaced after vaginal intercourse, cannot inhibit the growth of uropathogenic \n \n Escherichia coli<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>. Thus, this bloom in \n \n S. mitis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> may provide a window of opportunity for a uropathogen to colonize the LUT.<\/jats:p>","DOI":"10.1099\/mgen.0.000535","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T15:20:30Z","timestamp":1614266430000},"source":"Crossref","is-referenced-by-count":12,"title":["Genomic relatedness and clinical significance of Streptococcus mitis strains isolated from the urogenital tract of sexual partners"],"prefix":"10.1099","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-2461","authenticated-orcid":false,"given":"Carine R.","family":"Mores","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA"},{"name":"Present address: Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9354-4549","authenticated-orcid":false,"given":"Travis K.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA"},{"name":"Present address: Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-0684","authenticated-orcid":false,"given":"Birte","family":"Wolff","sequence":"additional","affiliation":[{"name":"Present address: Swedish Hospital, NorthShore University, Suite 605, 5140 N California Avenue, Chicago, IL 60625, USA"},{"name":"Department of Urology, Loyola University Medical Center, Maywood, IL 60153, USA"},{"name":"Department of Obstetrics and Gynecology, Loyola University Medical Center, 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