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However, the chitin metabolic pathway in\n \n \n V. cholerae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n has been dissected using only a limited number of laboratory strains of this species. Here, we survey the complement of key chitin metabolism genes amongst 195 diverse\n \n \n V. cholerae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n . We show that the gene encoding GbpA, known to be an important colonization and virulence factor in pandemic isolates, is not ubiquitous amongst\n \n \n V. cholerae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n . We also identify a putatively novel chitinase, and present experimental evidence in support of its functionality. Our data indicate that the chitin metabolic pathway within\n \n \n V. cholerae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n is more complex than previously thought, and emphasize the importance of considering genes and functions in the context of a species in its entirety, rather than simply relying on traditional reference strains.\n <\/jats:p>","DOI":"10.1099\/mgen.0.000594","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T10:17:12Z","timestamp":1623147432000},"source":"Crossref","is-referenced-by-count":4,"title":["gbpA and chiA genes are not uniformly distributed amongst diverse Vibrio cholerae"],"prefix":"10.1099","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3230-1452","authenticated-orcid":false,"given":"Thea G.","family":"Fennell","sequence":"first","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK"},{"name":"Churchill College, Storey\u2019s Way, Cambridge, CB3 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