{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:49:31Z","timestamp":1777499371853,"version":"3.51.4"},"reference-count":60,"publisher":"Microbiology Society","issue":"9","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1132412"],"award-info":[{"award-number":["1132412"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["212914\/Z\/18\/B"],"award-info":[{"award-number":["212914\/Z\/18\/B"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australian Government Research Training Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,9]]},"abstract":"<jats:p>Infection of <jats:italic>w<\/jats:italic>Mel <jats:italic>\n                     <jats:named-content content-type=\"genus\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1005\" xlink:type=\"simple\">Wolbachia<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> in <jats:italic>Aedes aegypti<\/jats:italic> imparts two signature features that enable its application for biocontrol of dengue. First, the susceptibility of mosquitoes to viruses such as dengue and Zika is reduced. Second, a reproductive manipulation is caused that enables <jats:italic>w<\/jats:italic>Mel introgression into wild-type mosquito populations. The long-term success of this method relies, in part, on evolution of the <jats:italic>w<\/jats:italic>Mel genome not compromising the critical features that make it an attractive biocontrol tool. This study compared the <jats:italic>w<\/jats:italic>Mel <jats:italic>\n                     <jats:named-content content-type=\"genus\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1005\" xlink:type=\"simple\">Wolbachia<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> genome at the time of initial releases and 1\u20137\u2009years post-release in Cairns, Australia. Our results show the <jats:italic>w<\/jats:italic>Mel genome remains highly conserved up to 7\u2009years post-release in gene sequence, content, synteny and structure. This work suggests the <jats:italic>w<\/jats:italic>Mel genome is stable in its new mosquito host and, therefore, provides reassurance on the potential for <jats:italic>w<\/jats:italic>Mel to deliver long-term public-health impacts.<\/jats:p>","DOI":"10.1099\/mgen.0.000641","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T13:17:21Z","timestamp":1630502241000},"source":"Crossref","is-referenced-by-count":16,"title":["wMel Wolbachia genome remains stable after 7 years in Australian Aedes aegypti field populations"],"prefix":"10.1099","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7960-1615","authenticated-orcid":false,"given":"Kimberley R.","family":"Dainty","sequence":"first","affiliation":[{"name":"Department of Microbiology, Monash University, Melbourne, Victoria, Australia"},{"name":"Institute of Vector-Borne Disease, Monash University, Melbourne, Victoria, 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