{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:38:24Z","timestamp":1791887904123,"version":"4.3.4"},"reference-count":21,"publisher":"Microbiology Society","issue":"11","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000836","name":"University of Liverpool","doi-asserted-by":"crossref","award":["RDF160301AC12"],"award-info":[{"award-number":["RDF160301AC12"]}],"id":[{"id":"10.13039\/501100000836","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["206545"],"award-info":[{"award-number":["206545"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,30]]},"abstract":"\n A special-care neonatal unit from a large public hospital in Malawi was noted as having more frequent, difficult-to-treat infections, and a suspected outbreak of multi-drug-resistant\n \n \n Klebsiella pneumoniae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n was investigated using genomic characterisation. All\n \n \n K. pneumoniae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n bloodstream infections (BSIs) from patients in the neonatal ward (\n n<\/jats:italic>\n =62), and a subset of\n \n \n K. pneumoniae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n BSI isolates (\n n<\/jats:italic>\n =38) from other paediatric wards in the hospital, collected over a 4\u2009year period were studied. After whole genome sequencing, the strain sequence types (STs), plasmid types, virulence and resistance genes were identified. One ST340 clone, part of clonal complex 258 (CC258) and an ST that drives hospital outbreaks worldwide, harbouring numerous resistance genes and plasmids, was implicated as the likely cause of the outbreak. This study contributes molecular information necessary for tracking and characterizing this important hospital pathogen in sub-Saharan Africa.\n <\/jats:p>","DOI":"10.1099\/mgen.0.000703","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T13:16:12Z","timestamp":1637241372000},"source":"Crossref","is-referenced-by-count":13,"title":["Genomic investigation of a suspected Klebsiella pneumoniae outbreak in a neonatal care unit in sub-Saharan Africa"],"prefix":"10.1099","volume":"7","author":[{"given":"Jennifer","family":"Cornick","sequence":"first","affiliation":[{"name":"Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi"},{"name":"Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, 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