{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:29:26Z","timestamp":1790123366882,"version":"4.0.1"},"reference-count":37,"publisher":"Microbiology Society","issue":"1","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa de Apoyo a Proyectos de Investigaci\u00f3n e Innovaci\u00f3n Tecnol\u00f3gica PAPIIT","award":["IN206019"],"award-info":[{"award-number":["IN206019"]}]},{"name":"CONACyT Ciencia B\u00e1sica","award":["284276"],"award-info":[{"award-number":["284276"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,17]]},"abstract":"\n Antimicrobial resistance (AR) is a major global threat to public health. Understanding the population dynamics of AR is critical to restrain and control this issue. However, no study has provided a global picture of the whole resistome of\n \n \n Acinetobacter baumannii<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n , a very important nosocomial pathogen. Here we analyse 1450+ genomes (covering >40 countries and >4 decades) to infer the global population dynamics of the resistome of this species. We show that gene flow and horizontal transfer have driven the dissemination of AR genes in\n \n \n A. baumannii<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n . We found considerable variation in AR gene content across lineages. Although the individual AR gene histories have been affected by recombination, the AR gene content has been shaped by the phylogeny. Furthermore, many AR genes have been transferred to other well-known pathogens, such as\n \n \n Pseudomonas aeruginosa<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n or\n \n \n Klebsiella pneumoniae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n . Despite using this massive data set, we were not able to sample the whole diversity of AR genes, which suggests that this species has an open resistome. Our results highlight the high mobilization risk of AR genes between important pathogens. On a broader perspective, this study gives a framework for an emerging perspective (resistome-centric) on the genomic epidemiology (and surveillance) of bacterial pathogens.\n <\/jats:p>","DOI":"10.1099\/mgen.0.000762","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T08:17:33Z","timestamp":1643098653000},"source":"Crossref","is-referenced-by-count":34,"title":["The promiscuous and highly mobile resistome of Acinetobacter baumannii"],"prefix":"10.1099","volume":"8","author":[{"given":"Ismael L","family":"Hern\u00e1ndez-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Programa de Gen\u00f3mica Evolutiva, Centro de Ciencias Gen\u00f3micas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Mateo-Estrada","sequence":"additional","affiliation":[{"name":"Programa de Gen\u00f3mica Evolutiva, Centro de Ciencias Gen\u00f3micas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-7088","authenticated-orcid":false,"given":"Santiago","family":"Castillo-Ramirez","sequence":"additional","affiliation":[{"name":"Programa de Gen\u00f3mica Evolutiva, Centro de Ciencias Gen\u00f3micas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00181-19"},{"key":"R2","article-title":"WHO publishes list of bacteria for which new antibiotics are urgently needed","year":"2017"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0423-1"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120800"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53886"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3399"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13803"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.09.002"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01817"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000309"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10020205"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00581-20"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01901"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00571-17"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000108"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00801-19"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2018.0311"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.670975"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000306"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1101\/gr.186072.114"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu153"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00626-21"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.000760"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.14826.1"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz935"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.105.048975"},{"key":"R28","volume-title":"vegan: Community Ecology Package. 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