{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:46:58Z","timestamp":1788929218884,"version":"build-2803163510"},"reference-count":33,"publisher":"Microbiology Society","issue":"1","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome","award":["215515\/Z\/19\/Z"],"award-info":[{"award-number":["215515\/Z\/19\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:p>\n                  <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.11017\" xlink:type=\"simple\">Salmonella enterica<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> Typhi (<jats:italic>S<\/jats:italic>. Typhi) and Paratyphi A (<jats:italic>S<\/jats:italic>. Paratyphi A) are the causative agents of enteric fever, a systemic human disease with a burden of 300\u200a000\u2009cases per year in India. The majority of enteric fever cases are associated with <jats:italic>S<\/jats:italic>. Typhi, resulting in a paucity of data regarding <jats:italic>S<\/jats:italic>. Paratyphi A, specifically with respect to genomic surveillance and antimicrobial resistance (AMR). Here, we exploited whole-genome sequencing (WGS) to identify <jats:italic>S<\/jats:italic>. Paratyphi A genotypes and AMR determinants associated with an outbreak of <jats:italic>S<\/jats:italic>. Paratyphi A in Vadodara, India, from December 2018 to December 2019. In total 117\u2009<jats:italic>S<\/jats:italic>. Paratyphi A were isolated and genome sequenced, most were genotype 2.4.2 (72.6\u200a% of all cases), which is the globally dominant genotype. The remainder were genotype 2.3 (25.6\u200a%), while only two isolates belonged to genotype 2.4.1. A single base-pair mutation in <jats:italic>gyrA<\/jats:italic>, associated with reduced susceptibility to fluoroquinolones, was present in all of the outbreak isolates; with 74.35\u200a% of isolates having a S83F substitution and the remainder having an S83Y substitution. Our surveillance study suggests that <jats:italic>S<\/jats:italic>. Paratyphi A is an emergent pathogen in South Asia, which may become increasingly relevant with the introduction of Vi conjugate vaccines.<\/jats:p>","DOI":"10.1099\/mgen.0.000914","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T15:16:56Z","timestamp":1673018216000},"source":"Crossref","is-referenced-by-count":7,"title":["The genomic characterization of Salmonella Paratyphi A from an outbreak of enteric fever in Vadodara, India"],"prefix":"10.1099","volume":"9","author":[{"given":"Joana","family":"Pereira-Dias","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK"},{"name":"University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Taneja","sequence":"additional","affiliation":[{"name":"Post Graduate Institute of Medical 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