{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:48:52Z","timestamp":1790779732428,"version":"4.1.0"},"reference-count":50,"publisher":"Microbiology Society","issue":"5","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["FL140100021"],"award-info":[{"award-number":["FL140100021"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["FT220100152"],"award-info":[{"award-number":["FT220100152"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["DE200100111"],"award-info":[{"award-number":["DE200100111"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,12]]},"abstract":"<jats:p>\n                  <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.2767\" xlink:type=\"simple\">Acinetobacter baumannii<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> is an important opportunistic pathogen known for its high levels of resistance to many antibiotics, particularly those considered last resorts such as colistin and carbapenems. Plasmids of this organism are increasingly associated with the spread of clinically important antibiotic resistance genes. Although <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.2767\" xlink:type=\"simple\">A. baumannii<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> is a ubiquitous organism, to date, most of the focus has been on studying strains recovered from clinical samples ignoring those isolated in the environment (soil, water, food, etc.). Here, we analysed the genetic structures of eight novel plasmids carried by an environmental colistin-resistant <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.2767\" xlink:type=\"simple\">A. baumannii<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> (strain E-072658) recovered in a recycled fibre pulp in a paper mill in Finland. It was shown that E-072658 carries a new variant of the <jats:italic>mcr-4<\/jats:italic> colistin resistance gene (<jats:italic>mcr-4.7<\/jats:italic>) in a novel Tn<jats:italic>3-<\/jats:italic>family transposon (called Tn<jats:italic>6926<\/jats:italic>) carried by a novel plasmid p8E072658. E-072658 is also resistant to sulphonamide compounds; consistent with this, the <jats:italic>sul2<\/jats:italic> sulphonamide resistance gene was found in a p<jats:italic>dif<\/jats:italic> module. E-072658 also carries six additional plasmids with no antibiotic resistance genes, but they contained several p<jats:italic>dif<\/jats:italic> modules shared with plasmids carried by clinical strains. Detailed analysis of the genetic structure of all eight plasmids carried by E-072658 showed a complex evolutionary history revealing genetic exchange events within the genus <jats:italic>\n                     <jats:named-content content-type=\"genus\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.2765\" xlink:type=\"simple\">Acinetobacter<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> beyond the clinical or environmental origin of the strains. This work provides evidence that environmental strains might act as a source for some of the clinically significant antibiotic resistance genes.<\/jats:p>","DOI":"10.1099\/mgen.0.001010","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T15:18:10Z","timestamp":1683904690000},"source":"Crossref","is-referenced-by-count":10,"title":["The evolutionary tale of eight novel plasmids in a colistin-resistant environmental Acinetobacter baumannii isolate"],"prefix":"10.1099","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-1686","authenticated-orcid":false,"given":"Farzana T.","family":"Prity","sequence":"first","affiliation":[{"name":"ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam A.","family":"Tobin","sequence":"additional","affiliation":[{"name":"Australian Institute for Microbiology & 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