{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:10:40Z","timestamp":1790777440720,"version":"4.1.0"},"reference-count":74,"publisher":"Microbiology Society","issue":"10","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000193","name":"International Development Research Centre","doi-asserted-by":"crossref","award":["108625"],"award-info":[{"award-number":["108625"]}],"id":[{"id":"10.13039\/501100000193","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000193","name":"International Development Research Centre","doi-asserted-by":"crossref","award":["108625"],"award-info":[{"award-number":["108625"]}],"id":[{"id":"10.13039\/501100000193","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000193","name":"International Development Research Centre","doi-asserted-by":"crossref","award":["108625"],"award-info":[{"award-number":["108625"]}],"id":[{"id":"10.13039\/501100000193","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000193","name":"International Development Research Centre","doi-asserted-by":"crossref","award":["108625"],"award-info":[{"award-number":["108625"]}],"id":[{"id":"10.13039\/501100000193","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,12]]},"abstract":"\n \n \n Mycoplasma feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> is a fast-growing \n \n Mycoplasma<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> species isolated from wild Caprinae<\/jats:italic> and first described in 2013. \n \n M. feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> isolates have been associated with arthritis, kerato conjunctivitis, pneumonia and septicemia, but were also recovered from apparently healthy animals. To better understand what defines this species, we performed a genomic survey on 14 strains collected from free-ranging or zoo-housed animals between 1987 and 2017, mostly in Europe. The average chromosome size of the \n \n M. feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> strains was 1,040\u00b10,024\u2009kbp, with 24\u200a% G+C\u2009and 852\u00b131\u2009CDS. The core genome and pan-genome of the \n \n M. feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> species contained 628 and 1312 protein families, respectively. The \n \n M. feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> strains displayed a relatively closed pan-genome, with many features and putative virulence factors shared with species from the \n \n M. mycoides<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> cluster, including the MIB-MIP Ig cleavage system, a repertoire of DUF285 surface proteins and a complete biosynthetic pathway for galactan. \n \n M. feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> genomes were found to be mostly syntenic, although repertoires of mobile genetic elements, including Mycoplasma Integrative and Conjugative Elements, insertion sequences, and a single plasmid varied. Phylogenetic- and gene content analyses confirmed that \n \n M. feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> was closer to the \n \n M. mycoides<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> cluster than to the ruminant species \n \n M. yeatsii<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> and \n \n M. putrefaciens<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>. Ancestral genome reconstruction showed that the emergence of the \n \n M. feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> species was associated with the gain of 17 gene families, some of which encode defence enzymes and surface proteins, and the loss of 25 others, some of which are involved in sugar transport and metabolism. This comparative study suggests that the \n \n M. mycoides<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> cluster could be extended to include \n \n M. feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>. We also find evidence that the specific organization and structure of the DnaA boxes around the oriC<\/jats:italic> of \n \n M. feriruminatoris<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> may contribute to drive the remarkable fast growth of this minimal bacterium.<\/jats:p>","DOI":"10.1099\/mgen.0.001112","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T12:16:50Z","timestamp":1697113010000},"source":"Crossref","is-referenced-by-count":5,"title":["Comparative genomics of Mycoplasma feriruminatoris, a fast-growing pathogen of wild Caprinae"],"prefix":"10.1099","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-1487","authenticated-orcid":false,"given":"Vincent","family":"Baby","sequence":"first","affiliation":[{"name":"Present address: CDVUM, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, 3200 rue Sicotte, St-Hyacinthe, QC, J2S 2M2, Canada"},{"name":"Universit\u00e9 de Bordeaux, INRAE, UMR BFP, F-33882, Villenave d\u2019Ornon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0558-6445","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Ambroset","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Anses\u2013Laboratoire de Lyon, VetAgro Sup, UMR Mycoplasmoses animales, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-8123","authenticated-orcid":false,"given":"Patrice","family":"Gaurivaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Anses\u2013Laboratoire de Lyon, VetAgro Sup, UMR Mycoplasmoses animales, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8102-7579","authenticated-orcid":false,"given":"Laurent","family":"Falquet","sequence":"additional","affiliation":[{"name":"Department of Biology, University 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