{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:08:14Z","timestamp":1788998894780,"version":"build-2803163510"},"reference-count":71,"publisher":"Microbiology Society","issue":"10","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R21AI128313"],"award-info":[{"award-number":["R21AI128313"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R21AI164733"],"award-info":[{"award-number":["R21AI164733"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01AI127863"],"award-info":[{"award-number":["R01AI127863"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,18]]},"abstract":"<jats:p>\n                  <jats:italic>Neisseria meningitidis (Nm<\/jats:italic>) is a bacterial pathogen responsible for invasive meningococcal disease. Though typically colonizing the nasopharynx, multiple outbreaks of meningococcal urethritis were first reported in 2015\u20132016; outbreaks originally presumed to be caused by <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1910\" xlink:type=\"simple\">Neisseria gonorrhoeae<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> (<jats:italic>Ng<\/jats:italic>). Genomic analysis revealed that the <jats:italic>Nm<\/jats:italic> isolates causing these outbreaks were a distinct clade, and had integrated gonococcal DNA at multiple genomic sites, including the gonococcal denitrification apparatus <jats:italic>aniA\u2013norB<\/jats:italic>, a partial gonococcal operon of five genes containing <jats:italic>isp<\/jats:italic>D, and the acetylglutamate kinase gene <jats:italic>argB<\/jats:italic> with the adjacent gonococcal locus <jats:italic>NGO0843<\/jats:italic>. The urethritis isolates had also deleted the group C capsule biosynthesis genes <jats:italic>cssA\/B\/C<\/jats:italic> and <jats:italic>csc<\/jats:italic>, resulting in loss of capsule. Collectively, these isolates form the <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1926\" xlink:type=\"simple\">N. meningitidis<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> urethritis clade (<jats:italic>Nm<\/jats:italic>UC). Genomic analysis of recent (2016\u20132022) <jats:italic>Nm<\/jats:italic>UC isolates revealed that the genomic features have been maintained in the clade, implying that they are important for <jats:italic>Nm<\/jats:italic>UC\u2019s status as a urogenital pathogen. Furthermore, the analysis revealed the emergence of a sub-clade, designated <jats:italic>Nm<\/jats:italic>UC-B, phylogenetically separated from the earlier <jats:italic>Nm<\/jats:italic>UC-A. This sub-clade has integrated additional gonococcal alleles into the genome, including alleles associated with antimicrobial resistance. <jats:italic>Nm<\/jats:italic>UC continues to adapt to a urethral niche and evolve as a urogenital pathogen.<\/jats:p>","DOI":"10.1099\/mgen.0.001113","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T14:18:18Z","timestamp":1697638698000},"source":"Crossref","is-referenced-by-count":11,"title":["Continuing genomic evolution of the Neisseria meningitidis cc11.2 urethritis clade, NmUC: a narrative review"],"prefix":"10.1099","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2633-6090","authenticated-orcid":false,"given":"Emilio I.","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7950-8197","authenticated-orcid":false,"given":"Yih-Ling","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-660X","authenticated-orcid":false,"given":"David S.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1086\/504804"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441807"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-346-2_1"},{"key":"R4","first-page":"1","article-title":"Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"62","author":"Cohn","year":"2013","journal-title":"MMWR Recomm Rep"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2021.11.016"},{"key":"R6","article-title":"Red book online outbreaks: Meningococcal disease in Florida","journal-title":"Red Book Online"},{"key":"R7","article-title":"Meningococcal disease outbreak among gay, Bisexual men in Florida, 2021\u201323","year":"2023"},{"key":"R8","volume-title":"Meningococcal Outbreak in Eastern Region","year":"2022"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.3998164"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7224a4"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5146-5153.2004"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.45529-0"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/123.1.67"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001205"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.02.062"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-023-04550-8"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.798575"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70251-6"},{"key":"R19","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1001\/jama.1980.03310180026026","article-title":"Prevalence and site-pathogen studies of Neisseria meningitidis and N gonorrhoeae in homosexual men","volume":"244","author":"Janda","year":"1980","journal-title":"JAMA"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac046"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260677"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00627-22"},{"key":"R23","article-title":"Gonorrhea \u2013 CDC Detailed Fact Sheet"},{"key":"R24","article-title":"Gonorrhoea (Neisseria gonorrhoeae infection)","year":"2023"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00010-14"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.169"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/0960-9822(93)90001-5"},{"key":"R28","volume-title":"Invasive Meningococcal Disease among Men Who Have Sex with Men. 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