{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:43:52Z","timestamp":1791495832542,"version":"4.3.4"},"reference-count":75,"publisher":"Microbiology Society","issue":"11","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"crossref","award":["12\/RC\/2273_P2 and 16\/SP\/3827"],"award-info":[{"award-number":["12\/RC\/2273_P2 and 16\/SP\/3827"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"crossref","award":["12\/RC\/2273_P2"],"award-info":[{"award-number":["12\/RC\/2273_P2"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"crossref","award":["EPSPD\/2016\/25"],"award-info":[{"award-number":["EPSPD\/2016\/25"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"crossref","award":["18\/CRT\/6214"],"award-info":[{"award-number":["18\/CRT\/6214"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Horizon 2020","award":["H2020-MSCA-COFUND-2019-945385"],"award-info":[{"award-number":["H2020-MSCA-COFUND-2019-945385"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,27]]},"abstract":"<jats:p>Each year, 15\u2009million infants are born preterm (&lt;37\u2009weeks gestation), representing the leading cause of mortality for children under the age of five. Whilst there is no single cause, factors such as maternal genetics, environmental interactions, and the vaginal microbiome have been associated with an increased risk of preterm birth. Previous studies show that a vaginal microbiota dominated by <jats:italic>\n                     <jats:named-content content-type=\"genus\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.5320\" xlink:type=\"simple\">Lactobacillus<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> is, in contrast to communities containing a mixture of genera, associated with full-term birth. However, this binary principle does not fully consider more nuanced interactions between bacterial strains and the host. Here, through a combination of analyses involving genome-sequenced isolates and strain-resolved metagenomics, we identify that <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.5383\" xlink:type=\"simple\">L. jensenii<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> strains from preterm pregnancies are phylogenetically distinct from strains from full-term pregnancies. Detailed analysis reveals several genetic signatures that distinguish preterm birth strains, including genes predicted to be involved in cell wall synthesis, and lactate and acetate metabolism. Notably, we identify a distinct gene cluster involved in cell surface protein synthesis in our preterm strains, and profiling the prevalence of this gene cluster in publicly available genomes revealed it to be predominantly present in the preterm-associated clade. This study contributes to the ongoing search for molecular biomarkers linked to preterm birth and opens up new avenues for exploring strain-level variations and mechanisms that may contribute to preterm birth.<\/jats:p>","DOI":"10.1099\/mgen.0.001137","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T16:17:20Z","timestamp":1701101840000},"source":"Crossref","is-referenced-by-count":7,"title":["Profiling of vaginal Lactobacillus jensenii isolated from preterm and full-term pregnancies reveals strain-specific factors relating to host interaction"],"prefix":"10.1099","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-3156","authenticated-orcid":false,"given":"Sai Ravi Chandra","family":"Nori","sequence":"first","affiliation":[{"name":"Teagasc Food Research Centre, Fermoy, Co. Cork, Ireland"},{"name":"SFI Centre for Research Training in Genomics Data Science, School of Mathematics, Statistics & Applied Mathematics, University of Galway, Galway, Ireland"},{"name":"APC Microbiome Ireland, University College Cork, Cork, Ireland"},{"name":"School of Microbiology, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara K.","family":"McGuire","sequence":"additional","affiliation":[{"name":"Teagasc Food Research Centre, Fermoy, Co. Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M.","family":"Lawton","sequence":"additional","affiliation":[{"name":"Teagasc Food Research Centre, Fermoy, Co. Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3477-6494","authenticated-orcid":false,"given":"Fionnuala M.","family":"McAuliffe","sequence":"additional","affiliation":[{"name":"UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1823-7957","authenticated-orcid":false,"given":"Douwe Van","family":"Sinderen","sequence":"additional","affiliation":[{"name":"School of Microbiology, University College Cork, Cork, Ireland"},{"name":"APC Microbiome Ireland, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-9534","authenticated-orcid":false,"given":"Calum J.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Peter Doherty Institute for Infection & Immunity, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5465-9068","authenticated-orcid":false,"given":"Paul D.","family":"Cotter","sequence":"additional","affiliation":[{"name":"APC Microbiome Ireland, University College Cork, Cork, Ireland"},{"name":"Teagasc Food Research Centre, Fermoy, Co. Cork, Ireland"},{"name":"School of Microbiology, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1253-7353","authenticated-orcid":false,"given":"Conor","family":"Feehily","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine, University of Oxford, Oxford, UK"},{"name":"Teagasc Food Research Centre, Fermoy, Co. Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002611107"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26905-0"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107758"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-200"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080074"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115867"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00446"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00460-13"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9051069"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3027"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/750479"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.801770"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.12.013"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3182631c79"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2006.12.005"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.339"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00311-4"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0450-2"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251816"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0299"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113488838"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1565919"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16352-y"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15300"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-020-00162-8"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705899114"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-2-18"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12007-9"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00615"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1530\/RAF-21-0065"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-019-00118-x"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2021.06.001"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.8.2571-2581.2003"},{"key":"R35","article-title":"FelixKrueger\/TrimGalore: v0.6.10 - add default decompression path","author":"Krueger","year":"2023"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.102"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv171"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt086"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1186\/S40168-018-0541-1\/FIGURES\/7"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16366-7"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv421"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf436"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msaa131"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab301"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu153"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msab293"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr039"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1017"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07641-9"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-112"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00433"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0464-9"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01293-8"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12080734"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28620-1"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.20517\/mrr.2022.03"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0667-9"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00943-20"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.01.166"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu231"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-022-02635-9"},{"key":"R64","article-title":"The discovery of different types of Cervical mucus and the billings ovulation method","author":"Odeblad","year":"1994","journal-title":"WOOMB International ltd"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1136\/sti.77.6.402"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069528"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00187-08"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2007.03516.x"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.10.3384-3390.2005"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.9.2910-2919.2003"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00731-13"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.3389\/FMICB.2020.00233\/BIBTEX"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2016.00048"},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1123"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.7.2903-2907.2001"}],"container-title":["Microbial Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/mgen\/10.1099\/mgen.0.001137?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T16:17:32Z","timestamp":1701101852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/mgen\/10.1099\/mgen.0.001137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":75,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11,27]]}},"URL":"https:\/\/doi.org\/10.1099\/mgen.0.001137","relation":{},"ISSN":["2057-5858"],"issn-type":[{"value":"2057-5858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]}}}